Scott Heyward

Affiliations

BioIVT, 1450 S Rolling Road, Halethorpe, MD 21227, USA.

Publications (25)

Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes.

Cells

Avec: Zhihui Li , Linhao Li , Scott Heyward , Shuaiqian Men , Meishu Xu , Tatsuya Sueyoshi , Hongbing Wang

Quantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling.

Molecular pharmaceutics

Avec: Sheena Sharma , Dilip K Singh , Vijay S Mettu , Guihua Yue , Deepak Ahire , Abdul Basit , Scott Heyward , Bhagwat Prasad

Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Sandhya Subash , Dilip K Singh , Deepak S Ahire , S Cyrus Khojasteh , Bernard P Murray , Michael A Zientek , Robert S Jones , Priyanka Kulkarni , Bill J Smith , Scott Heyward , Ciarán N Cronin , Bhagwat Prasad

An 8-week physiotherapist-led return to sport group program after anterior cruciate ligament reconstruction improves measures of physical and psychological function: A case series.

Musculoskeletal science & practice

Avec: Adam Walker , Larissa Sattler , Samuel Heyward , Jordan Tedesco , Zachariah Jones , Corey D'Lima , Caroline Higham , Sophie Cuthbert , Wayne Hing

Molecular pharmacology

Avec: Kaiyan Liu , Zhihui Li , Linhao Li , Scott Heyward , Shelley R Wang , Ling He , Hongbing Wang

Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation.

International journal of molecular sciences

Avec: Theresa Aliwarga , Jean C Dinh , Scott Heyward , Bhagwat Prasad , Sina A Gharib , Rozenn N Lemaitre , Nona Sotoodehnia , Rheem A Totah

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: Caitlin Lynch , Bryan Mackowiak , Ruili Huang , Linhao Li , Scott Heyward , Srilatha Sakamuru , Hongbing Wang , Menghang Xia

Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Md Masud Parvez , Abdul Basit , Parth B Jariwala , Zsuzsanna Gáborik , Emese Kis , Scott Heyward , Matthew R Redinbo , Bhagwat Prasad

Relevance of Human Aldoketoreductases and Microbial

Drug metabolism and disposition: the biological fate of chemicals

Avec: Abdul Basit , John K Amory , Vijaya Saradhi Mettu , Cindy Yanfei Li , Scott Heyward , Parth B Jariwala , Matthew R Redinbo , Bhagwat Prasad

Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients.

Hepatology communications

Avec: Kaiyan Liu , Sydney Stern , Emily L Heil , Linhao Li , Rula Khairi , Scott Heyward , Hongbing Wang

Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression.

Pharmaceutical research

Avec: Brandy Garzel , Tao Hu , Linhao Li , Yuanfu Lu , Scott Heyward , James Polli , Lei Zhang , Shiew-Mei Huang , Jean-Pierre Raufman , Hongbing Wang

Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Abdul Basit , Peter W Fan , S Cyrus Khojasteh , Bernard P Murray , Bill J Smith , Scott Heyward , Bhagwat Prasad

Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Vineet Kumar , Mengyue Yin , Kazuya Ishida , Laurent Salphati , Cornelis E C A Hop , Christopher Rowbottom , Guangqing Xiao , Yurong Lai , Anita Mathias , Xiaoyan Chu , W Griffith Humphreys , Mingxiang Liao , Zsuzsanna Nerada , Nóra Szilvásy , Scott Heyward , Jashvant D Unadkat

Prediction of Hepatobiliary Clearances and Hepatic Concentrations of Transported Drugs in Humans Using Rosuvastatin as a Model Drug.

Clinical pharmacology and therapeutics

Avec: Flavia Storelli , Cindy Yanfei Li , Madhav Sachar , Vineet Kumar , Scott Heyward , Zsolt Sáfár , Emese Kis , Jashvant D Unadkat

Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Kirk D Kozminski , Jangir Selimkhanov , Scott Heyward , Michael A Zientek

Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism.

Molecular pharmaceutics

Avec: Sandhya Subash , Dilip K Singh , Deepak Ahire , S Cyrus Khojasteh , Bernard P Murray , Michael A Zientek , Robert S Jones , Priyanka Kulkarni , Faizan Zubair , Bill J Smith , Scott Heyward , J Steven Leeder , Bhagwat Prasad

Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.

European journal of medicinal chemistry

Avec: Dongdong Liang , Linhao Li , Caitlin Lynch , Bryan Mackowiak , William D Hedrich , Yong Ai , Yue Yin , Scott Heyward , Menghang Xia , Hongbing Wang , Fengtian Xue

Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor.

Molecular pharmacology

Avec: Linhao Li , Matthew A Welch , Zhihui Li , Bryan Mackowiak , Scott Heyward , Peter W Swaan , Hongbing Wang

High-content analysis of constitutive androstane receptor (CAR) translocation identifies mosapride citrate as a CAR agonist that represses gluconeogenesis.

Biochemical pharmacology

Avec: Bryan Mackowiak , Linhao Li , Caitlin Lynch , Andrew Ziman , Scott Heyward , Menghang Xia , Hongbing Wang

A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Vineet Kumar , Laurent Salphati , Cornelis E C A Hop , Guangqing Xiao , Yurong Lai , Anita Mathias , Xiaoyan Chu , W Griffith Humphreys , Mingxiang Liao , Scott Heyward , Jashvant D Unadkat

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration.

Clinical and translational science

Avec: Hongbing Wang , Paul C Brown , Edwin C Y Chow , Lorna Ewart , Stephen S Ferguson , Suzanne Fitzpatrick , Benjamin S Freedman , Grace L Guo , William Hedrich , Scott Heyward , James Hickman , Nina Isoherranen , Albert P Li , Qi Liu , Shannon M Mumenthaler , James Polli , William R Proctor , Alexandre Ribeiro , Jian-Ying Wang , Ronald L Wange , Shiew-Mei Huang

Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human.

Molecular pharmaceutics

Avec: Abdul Basit , Naveen K Neradugomma , Christopher Wolford , Peter W Fan , Bernard Murray , Ryan H Takahashi , S Cyrus Khojasteh , Bill J Smith , Scott Heyward , Rheem A Totah , Edward J Kelly , Bhagwat Prasad

Targeting CAR and Nrf2 improves cyclophosphamide bioactivation while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment.

JCI insight

Avec: Sydney Stern , Dongdong Liang , Linhao Li , Ritika Kurian , Caitlin Lynch , Srilatha Sakamuru , Scott Heyward , Junran Zhang , Kafayat Ajoke Kareem , Young Wook Chun , Ruili Huang , Menghang Xia , Charles C Hong , Fengtian Xue , Hongbing Wang

Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Sheena Sharma , Deepak Ahire , Abdul Basit , Maria Lajoie , Christina Wang , Min S Lee , Diana L Blithe , John K Amory , Dilip K Singh , Scott Heyward , Bhagwat Prasad

Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations.

Clinical pharmacology and therapeutics

Avec: Deepak Ahire , Scott Heyward , Bhagwat Prasad

Réseau de co-auteurs

Hongbing Wang 10 collaborations

Bhagwat Prasad 10 collaborations

Linhao Li 9 collaborations

Abdul Basit 6 collaborations

Dilip K Singh 4 collaborations

Deepak Ahire 4 collaborations

S Cyrus Khojasteh 4 collaborations

Bill J Smith 4 collaborations

Caitlin Lynch 4 collaborations

Bryan Mackowiak 4 collaborations

Menghang Xia 4 collaborations

Zhihui Li 3 collaborations

Bernard P Murray 3 collaborations

Michael A Zientek 3 collaborations

Vineet Kumar 3 collaborations

Jashvant D Unadkat 3 collaborations

Sheena Sharma 2 collaborations

Sandhya Subash 2 collaborations

Robert S Jones 2 collaborations

Priyanka Kulkarni 2 collaborations

Kaiyan Liu 2 collaborations

Rheem A Totah 2 collaborations

Ruili Huang 2 collaborations

Srilatha Sakamuru 2 collaborations

Parth B Jariwala 2 collaborations

Emese Kis 2 collaborations

Matthew R Redinbo 2 collaborations

John K Amory 2 collaborations

Cindy Yanfei Li 2 collaborations

Sydney Stern 2 collaborations

James Polli 2 collaborations

Shiew-Mei Huang 2 collaborations

Peter W Fan 2 collaborations

Laurent Salphati 2 collaborations

Cornelis E C A Hop 2 collaborations

Guangqing Xiao 2 collaborations

Yurong Lai 2 collaborations

Anita Mathias 2 collaborations

Xiaoyan Chu 2 collaborations

W Griffith Humphreys 2 collaborations

Mingxiang Liao 2 collaborations

Dongdong Liang 2 collaborations

Fengtian Xue 2 collaborations

Shuaiqian Men 1 collaboration

Meishu Xu 1 collaboration

Tatsuya Sueyoshi 1 collaboration

Vijay S Mettu 1 collaboration

Guihua Yue 1 collaboration

Deepak S Ahire 1 collaboration

Ciarán N Cronin 1 collaboration

Adam Walker 1 collaboration

Larissa Sattler 1 collaboration

Samuel Heyward 1 collaboration

Jordan Tedesco 1 collaboration

Zachariah Jones 1 collaboration

Corey D'Lima 1 collaboration

Caroline Higham 1 collaboration

Sophie Cuthbert 1 collaboration

Wayne Hing 1 collaboration

Shelley R Wang 1 collaboration

Ling He 1 collaboration

Theresa Aliwarga 1 collaboration

Jean C Dinh 1 collaboration

Sina A Gharib 1 collaboration

Rozenn N Lemaitre 1 collaboration

Nona Sotoodehnia 1 collaboration

Md Masud Parvez 1 collaboration

Zsuzsanna Gáborik 1 collaboration

Vijaya Saradhi Mettu 1 collaboration

Emily L Heil 1 collaboration

Rula Khairi 1 collaboration

Brandy Garzel 1 collaboration

Tao Hu 1 collaboration

Yuanfu Lu 1 collaboration

Lei Zhang 1 collaboration

Jean-Pierre Raufman 1 collaboration

Mengyue Yin 1 collaboration

Kazuya Ishida 1 collaboration

Christopher Rowbottom 1 collaboration

Zsuzsanna Nerada 1 collaboration

Nóra Szilvásy 1 collaboration

Flavia Storelli 1 collaboration

Madhav Sachar 1 collaboration

Zsolt Sáfár 1 collaboration

Kirk D Kozminski 1 collaboration

Jangir Selimkhanov 1 collaboration

Faizan Zubair 1 collaboration

J Steven Leeder 1 collaboration

William D Hedrich 1 collaboration

Yong Ai 1 collaboration

Yue Yin 1 collaboration

Matthew A Welch 1 collaboration

Peter W Swaan 1 collaboration

Andrew Ziman 1 collaboration

Paul C Brown 1 collaboration

Edwin C Y Chow 1 collaboration

Lorna Ewart 1 collaboration

Stephen S Ferguson 1 collaboration

Suzanne Fitzpatrick 1 collaboration

Benjamin S Freedman 1 collaboration

Grace L Guo 1 collaboration

William Hedrich 1 collaboration

James Hickman 1 collaboration

Nina Isoherranen 1 collaboration

Albert P Li 1 collaboration

Qi Liu 1 collaboration

Shannon M Mumenthaler 1 collaboration

William R Proctor 1 collaboration

Alexandre Ribeiro 1 collaboration

Jian-Ying Wang 1 collaboration

Ronald L Wange 1 collaboration

Naveen K Neradugomma 1 collaboration

Christopher Wolford 1 collaboration

Bernard Murray 1 collaboration

Ryan H Takahashi 1 collaboration

Edward J Kelly 1 collaboration

Ritika Kurian 1 collaboration

Junran Zhang 1 collaboration

Kafayat Ajoke Kareem 1 collaboration

Young Wook Chun 1 collaboration

Charles C Hong 1 collaboration

Maria Lajoie 1 collaboration

Christina Wang 1 collaboration

Min S Lee 1 collaboration

Diana L Blithe 1 collaboration