Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism.

aldehyde oxidase drug metabolism ontogeny quantitative proteomics

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
08 May 2024
Historique:
medline: 8 5 2024
pubmed: 8 5 2024
entrez: 8 5 2024
Statut: aheadofprint

Résumé

Despite the increasing importance of aldehyde oxidase (AO) in the drug metabolism of clinical candidates, ontogeny data for AO are limited. The objective of our study was to characterize the age-dependent AO content and activity in the human liver cytosolic fraction (HLC) and human hepatocytes (HH). HLC (

Identifiants

DOI: 10.1021/acs.molpharmaceut.3c01147 PMID: 38717252
pubmed: 38717252
doi: 10.1021/acs.molpharmaceut.3c01147
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Sandhya Subash (S)

College of Pharmacy and Pharmaceutical Sciences, Washington State University (WSU), Spokane, Washington 99202, United States.

Dilip K Singh (DK)

College of Pharmacy and Pharmaceutical Sciences, Washington State University (WSU), Spokane, Washington 99202, United States.

Deepak Ahire (D)

College of Pharmacy and Pharmaceutical Sciences, Washington State University (WSU), Spokane, Washington 99202, United States.
ORCID: 0000-0001-8537-6047

S Cyrus Khojasteh (SC)

Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California 94080, United States.

Bernard P Murray (BP)

Drug Metabolism, Gilead Sciences, Inc., Foster City, California 94404, United States.

Michael A Zientek (MA)

Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc., San Diego, California 92121, United States.

Robert S Jones (RS)

Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California 94080, United States.

Priyanka Kulkarni (P)

Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, United States.

Faizan Zubair (F)

Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc., San Diego, California 92121, United States.

Bill J Smith (BJ)

Terminal Phase Consulting LLC, Colorado Springs, Colorado 94404, United States.

Scott Heyward (S)

BioIVT, Inc., Baltimore, Maryland 21227, United States.

J Steven Leeder (JS)

Department of Pediatrics, Children's Mercy Hospital, Kansas City, Missouri 64108, United States.

Bhagwat Prasad (B)

College of Pharmacy and Pharmaceutical Sciences, Washington State University (WSU), Spokane, Washington 99202, United States.
ORCID: 0000-0002-9090-0912

Classifications MeSH