Oleuropein-Induced Acceleration of Cytochrome P450-Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor α.

Animals Anti-Inflammatory Agents / pharmacokinetics Cardiotonic Agents / pharmacokinetics Cytochrome P-450 Enzyme System / classification Drug Interactions Gene Expression Regulation Inactivation, Metabolic / drug effects Iridoid Glucosides / pharmacokinetics Mice Oleaceae PPAR alpha / metabolism Phytochemicals / pharmacokinetics Prescription Drugs / pharmacokinetics

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
09 2021
Historique:
received: 11 04 2020
accepted: 06 04 2021
pubmed: 25 6 2021
medline: 25 3 2022
entrez: 24 6 2021
Statut: ppublish

Résumé

Oleuropein (OLE), the main constituent of

Identifiants

DOI: 10.1124/dmd.120.000302 PMID: 34162688
pubmed: 34162688
pii: dmd.120.000302
doi: 10.1124/dmd.120.000302
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Cardiotonic Agents 0
Iridoid Glucosides 0
PPAR alpha 0
Phytochemicals 0
Ppara protein, mouse 0
Prescription Drugs 0
oleuropein 2O4553545L
Cytochrome P-450 Enzyme System 9035-51-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

833-843

Informations de copyright

U.S. Government work not protected by U.S. copyright.

Auteurs

Foteini Malliou (F)

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece (F.M., C.E.A., A.K., M.K.); Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and Faculty of Pharmacy, School of Health Sciences, University of Athens, Athens, Greece (A.-L.S.).

Christina E Andriopoulou (CE)

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece (F.M., C.E.A., A.K., M.K.); Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and Faculty of Pharmacy, School of Health Sciences, University of Athens, Athens, Greece (A.-L.S.).

Frank J Gonzalez (FJ)

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece (F.M., C.E.A., A.K., M.K.); Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and Faculty of Pharmacy, School of Health Sciences, University of Athens, Athens, Greece (A.-L.S.).

Aristeidis Kofinas (A)

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece (F.M., C.E.A., A.K., M.K.); Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and Faculty of Pharmacy, School of Health Sciences, University of Athens, Athens, Greece (A.-L.S.).

Alexios-Leandros Skaltsounis (AL)

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece (F.M., C.E.A., A.K., M.K.); Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and Faculty of Pharmacy, School of Health Sciences, University of Athens, Athens, Greece (A.-L.S.).

Maria Konstandi (M)

Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece (F.M., C.E.A., A.K., M.K.); Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and Faculty of Pharmacy, School of Health Sciences, University of Athens, Athens, Greece (A.-L.S.) mkonstan@uoi.gr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Cardiotoniques › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Inactivation métabolique › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Glucides › Hétérosides › Glycosides d'iridoïdes › Glucosides d'iridoïdes › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Oleaceae › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Oleuropein-Induced Acceleration of Cytochrome...
questionsmedicales.fr › Préparations pharmaceutiques › Médicaments sur ordonnance › Oleuropein-Induced Acceleration of Cytochrome...