Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study.
All-cause mortality
Asymptomatic organ damage
Cardiovascular disease
Disease prevention
Prediabetes
Type 2 diabetes mellitus
Journal
Clinical research in cardiology : official journal of the German Cardiac Society
ISSN: 1861-0692
Titre abrégé: Clin Res Cardiol
Pays: Germany
ID NLM: 101264123
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
12
04
2021
accepted:
25
05
2021
pubmed:
26
6
2021
medline:
5
3
2022
entrez:
25
6
2021
Statut:
ppublish
Résumé
To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the general population and to investigate the associated cardiovascular burden and clinical outcome. The study sample comprised 15,010 individuals aged 35-74 years of the population-based Gutenberg Health Study. Subjects were classified into euglycaemia, prediabetes and T2DM according to clinical and metabolic (HbA1c) information. The prevalence of prediabetes was 9.5% (n = 1415) and of T2DM 8.9% (n = 1316). Prediabetes and T2DM showed a significantly increased prevalence ratio (PR) for age, obesity, active smoking, dyslipidemia, and arterial hypertension compared to euglycaemia (for all, P < 0.0001). In a robust Poisson regression analysis, prediabetes was established as an independent predictor of clinically-prevalent cardiovascular disease (PR Besides T2DM, also prediabetes inherits a significant cardiovascular burden, which translates into poor clinical outcome and indicates the need for new concepts regarding the prevention of cardiometabolic disorders.
Identifiants
pubmed: 34169342
doi: 10.1007/s00392-021-01879-y
pii: 10.1007/s00392-021-01879-y
pmc: PMC8873120
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
272-283Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : BMBF 01EO1503
Organisme : Bundesministerium für Bildung und Forschung
ID : BMBF 161L0217A
Informations de copyright
© 2021. The Author(s).
Références
Circulation. 1998 May 12;97(18):1837-47
pubmed: 9603539
BMJ. 2020 Jul 15;370:m2297
pubmed: 32669282
Diabetes Care. 2009 Jul;32(7):1327-34
pubmed: 19502545
J Physiol Pharmacol. 2019 Dec;70(6):
pubmed: 32084643
BMJ. 2016 Nov 23;355:i5953
pubmed: 27881363
J Am Coll Cardiol. 2010 Mar 30;55(13):1310-7
pubmed: 20338491
Clin Biochem. 2015 Jun;48(9):581-5
pubmed: 25753569
J Clin Med. 2020 Oct 13;9(10):
pubmed: 33066307
Diabetes Care. 1990 Jun;13(6):631-54
pubmed: 2192848
Endocrinol Metab Clin North Am. 2018 Mar;47(1):33-50
pubmed: 29407055
Circulation. 2013 Feb 12;127(6):749-56
pubmed: 23401116
Lancet Diabetes Endocrinol. 2018 May;6(5):361-369
pubmed: 29503172
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012 Jun;55(6-7):824-9
pubmed: 22736163
N Engl J Med. 2012 Dec 20;367(25):2375-84
pubmed: 23121323
Eur Heart J. 2016 Aug 1;37(29):2315-2381
pubmed: 27222591
Diabetes Care. 2021 Jan;44(Suppl 1):S34-S39
pubmed: 33298414
Diabet Med. 2012 Jul;29(7):e88-95
pubmed: 22248078
J Am Heart Assoc. 2019 Oct 15;8(20):e012509
pubmed: 31583936
Diabetes. 2013 May;62(5):1386-8
pubmed: 23613560
Lancet. 2016 Apr 9;387(10027):1513-1530
pubmed: 27061677
Diabetes Care. 2015 Jul;38(7):1356-64
pubmed: 25877811
Circulation. 1991 Sep;84(3):1165-75
pubmed: 1884447
PLoS One. 2014 Nov 17;9(11):e113154
pubmed: 25402347
Diabetes. 2004 Dec;53 Suppl 3:S16-21
pubmed: 15561905
Nat Med. 2021 Jan;27(1):49-57
pubmed: 33398163
Lancet. 2012 Jun 16;379(9833):2279-90
pubmed: 22683128
Diabetes Res Clin Pract. 2020 Feb;160:107994
pubmed: 31881240
Endocrine. 2013 Jun;43(3):504-13
pubmed: 23132321
Am J Cardiol. 2011 Aug 2;108(3 Suppl):3B-24B
pubmed: 21802577
BMJ. 2012 Jul 12;345:e4624
pubmed: 22791792