Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis.
Adolescent
Altruism
Birth Cohort
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Cordocentesis
/ methods
CpG Islands
/ genetics
DNA Methylation
/ genetics
Epigenesis, Genetic
/ genetics
Epigenome
/ genetics
Epigenomics
/ methods
Female
Fetal Blood
/ metabolism
Genome-Wide Association Study
/ methods
Humans
Infant, Newborn
/ metabolism
Male
DNA methylation
cord blood
epigenome-wide association study
meta-analysis
prosocial behavior
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
26
05
2021
received:
11
11
2020
accepted:
02
06
2021
pubmed:
26
6
2021
medline:
5
1
2022
entrez:
25
6
2021
Statut:
ppublish
Résumé
Low prosocial behavior in childhood has been consistently linked to later psychopathology, with evidence supporting the influence of both genetic and environmental factors on its development. Although neonatal DNA methylation (DNAm) has been found to prospectively associate with a range of psychological traits in childhood, its potential role in prosocial development has yet to be investigated. This study investigated prospective associations between cord blood DNAm at birth and low prosocial behavior within and across four longitudinal birth cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium. We examined (a) developmental trajectories of "chronic-low" versus "typical" prosocial behavior across childhood in a case-control design (N = 2,095), and (b) continuous "low prosocial" scores at comparable cross-cohort time-points (N = 2,121). Meta-analyses were performed to examine differentially methylated positions and regions. At the cohort-specific level, three CpGs were found to associate with chronic low prosocial behavior; however, none of these associations was replicated in another cohort. Meta-analysis revealed no epigenome-wide significant CpGs or regions. Overall, we found no evidence for associations between DNAm patterns at birth and low prosocial behavior across childhood. Findings highlight the importance of employing multi-cohort approaches to replicate epigenetic associations and reduce the risk of false positive discoveries.
Identifiants
pubmed: 34170065
doi: 10.1002/ajmg.b.32862
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
228-241Subventions
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01HD068437
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S03658X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
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