1,2,3,4-Tetrahydroisoquinoline Derivatives as a Novel Deoxyribonuclease I Inhibitors.
Apoptosis
/ drug effects
Binding Sites
Catalytic Domain
Cell Line
Deoxyribonuclease I
/ antagonists & inhibitors
Enzyme Inhibitors
/ chemistry
Humans
Inhibitory Concentration 50
Molecular Docking Simulation
Molecular Dynamics Simulation
Structure-Activity Relationship
Tetrahydroisoquinolines
/ chemistry
DNase I
enzyme inhibition
molecular docking
molecular dynamics
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
02
04
2021
accepted:
25
06
2021
pubmed:
26
6
2021
medline:
13
10
2021
entrez:
25
6
2021
Statut:
ppublish
Résumé
Herein we report an assessment of 24 1,2,3,4-tetrahydroisoquinoline derivatives for potential DNase I (deoxyribonuclease I) inhibitory properties in vitro. Four of them inhibited DNase I with IC
Identifiants
pubmed: 34170076
doi: 10.1002/cbdv.202100261
doi:
Substances chimiques
Enzyme Inhibitors
0
Tetrahydroisoquinolines
0
1,2,3,4-tetrahydroisoquinoline
56W89FBX3E
Deoxyribonuclease I
EC 3.1.21.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100261Subventions
Organisme : Ministry of Education, Science and Technological Development of the Republic of Serbia
ID : 451-03-68/2020-14/200113
Organisme : Ministry of Education, Science and Technological Development of the Republic of Serbia
ID : 451-03-9/2021-14/200026
Organisme : Faculty of Medicine of the University of Niš
ID : 40
Informations de copyright
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
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