A meta-analysis of blood and salivary cortisol levels in first-episode psychosis and high-risk individuals.
Early intervention
HPA axis
Psychosis risk
Schizophrenia
Stress
Journal
Frontiers in neuroendocrinology
ISSN: 1095-6808
Titre abrégé: Front Neuroendocrinol
Pays: United States
ID NLM: 7513292
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
07
03
2021
revised:
10
06
2021
accepted:
19
06
2021
pubmed:
26
6
2021
medline:
26
10
2021
entrez:
25
6
2021
Statut:
ppublish
Résumé
Dysregulated cortisol responses and glucose metabolism have been reported in psychosis. We performed a random-effects meta-analysis of cortisol responses in first-episode psychosis (FEP) and psychosis risk states, taking into consideration glucose metabolism. A total of 47 studies were included. Unstimulated blood cortisol levels were significantly higher (g = 0.48, 95 %CI: 0.25-0.70, p < 0.001) in FEP, but not in psychosis risk states (g = 0.39, 95 %CI: -0.42-1.21, p = 0.342), compared to controls. Cortisol awakening response (CAR) was attenuated in FEP (g = -0.40, 95 %CI: -0.68 - -0.12, p = 0.006), but not in psychosis risk states (p = 0.433). Glucose and insulin levels were positively correlated with unstimulated blood cortisol levels in FEP. Our meta-analysis supports previous findings of elevated blood cortisol levels and attenuated CAR in FEP. Future research should focus on identifying the common denominators for alterations in stress hormones and glucose metabolism.
Identifiants
pubmed: 34171354
pii: S0091-3022(21)00032-7
doi: 10.1016/j.yfrne.2021.100930
pii:
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100930Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.