Constipation and diabetic kidney disease: The Fukuoka Diabetes Registry.
Aged
Albuminuria
/ etiology
Cohort Studies
Constipation
/ drug therapy
Creatinine
/ urine
Defecation
Diabetes Mellitus, Type 2
/ epidemiology
Diabetic Nephropathies
/ complications
Female
Glomerular Filtration Rate
Humans
Japan
/ epidemiology
Laxatives
/ therapeutic use
Male
Middle Aged
Odds Ratio
Prevalence
Registries
Albuminuria
Chronic kidney disease
Constipation
Diabetes
Laxative
Journal
Clinical and experimental nephrology
ISSN: 1437-7799
Titre abrégé: Clin Exp Nephrol
Pays: Japan
ID NLM: 9709923
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
21
05
2021
accepted:
21
06
2021
pubmed:
27
6
2021
medline:
27
1
2022
entrez:
26
6
2021
Statut:
ppublish
Résumé
Constipation was shown to be associated with higher risk of end-stage kidney disease or incident chronic kidney disease, although evidence in diabetic patients is lacking. The objective of the present study was to examine the association between constipation and diabetic kidney disease (DKD). In total, 4826 Japanese outpatients with type 2 diabetes were classified according to presence or absence of constipation (defecation frequency < 3 times/week and/or taking laxative medication). DKD was defined as presence of decreased estimated glomerular filtration rate (eGFR < 60 ml/min/1.73 m Compared with participants without constipation, the age- and sex-adjusted odds ratio for presence of DKD was 1.58 (95% confidence interval 1.38-1.82) for those with constipation. This association persisted following adjustment for potential confounding factors. Decreased defecation frequency and laxative use were also significantly associated with higher prevalence of DKD. Overall, these findings were identical even when decreased eGFR and albuminuria were separately analyzed. Constipation was associated with higher likelihood of DKD in patients with diabetes, suggesting the importance of clinical assessment of constipation to identify patients at high risk of progression of kidney disease.
Sections du résumé
BACKGROUND
BACKGROUND
Constipation was shown to be associated with higher risk of end-stage kidney disease or incident chronic kidney disease, although evidence in diabetic patients is lacking. The objective of the present study was to examine the association between constipation and diabetic kidney disease (DKD).
METHODS
METHODS
In total, 4826 Japanese outpatients with type 2 diabetes were classified according to presence or absence of constipation (defecation frequency < 3 times/week and/or taking laxative medication). DKD was defined as presence of decreased estimated glomerular filtration rate (eGFR < 60 ml/min/1.73 m
RESULTS
RESULTS
Compared with participants without constipation, the age- and sex-adjusted odds ratio for presence of DKD was 1.58 (95% confidence interval 1.38-1.82) for those with constipation. This association persisted following adjustment for potential confounding factors. Decreased defecation frequency and laxative use were also significantly associated with higher prevalence of DKD. Overall, these findings were identical even when decreased eGFR and albuminuria were separately analyzed.
CONCLUSIONS
CONCLUSIONS
Constipation was associated with higher likelihood of DKD in patients with diabetes, suggesting the importance of clinical assessment of constipation to identify patients at high risk of progression of kidney disease.
Identifiants
pubmed: 34173920
doi: 10.1007/s10157-021-02105-9
pii: 10.1007/s10157-021-02105-9
doi:
Substances chimiques
Laxatives
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1247-1254Subventions
Organisme : The Japan Society for the Promotion of Science (KAKENHI)
ID : 19K24229
Organisme : The Japan Society for the Promotion of Science (KAKENHI)
ID : 21K11700
Organisme : The Japan Society for the Promotion of Science (KAKENHI)
ID : 23249037
Organisme : The Japan Society for the Promotion of Science (KAKENHI)
ID : 23659353
Organisme : The Japan Society for the Promotion of Science (KAKENHI)
ID : 16K00861
Organisme : The Japan Society for the Promotion of Science (KAKENHI)
ID : 20K19663
Informations de copyright
© 2021. Japanese Society of Nephrology.
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