In vivo imaging of synaptic density with [

Aging Alzheimer Disease Amyloid beta-Peptides / analysis Animals Area Under Curve Brain / diagnostic imaging Carbon Radioisotopes / pharmacokinetics Disease Models, Animal Membrane Glycoproteins / analysis Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins / analysis Organ Specificity Parkinson Disease Peptide Fragments / analysis Positron-Emission Tomography / methods Pyridines / pharmacokinetics Pyrrolidinones / pharmacokinetics Radiopharmaceuticals / pharmacokinetics Synaptic Vesicles / ultrastructure Synucleinopathies / diagnostic imaging
Alzheimer's disease Parkinson's disease Positron emission tomography (PET) Synaptic density Transgenic mouse models [(11c]ucb-j)

Journal

NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515

Informations de publication

Date de publication:
01 10 2021
Historique:
received: 23 02 2021
revised: 15 06 2021
accepted: 22 06 2021
pubmed: 27 6 2021
medline: 29 10 2021
entrez: 26 6 2021
Statut: ppublish

Résumé

The positron emission tomography (PET) radioligand [

Identifiants

DOI: 10.1016/j.neuroimage.2021.118302 PMID: 34174391
pubmed: 34174391
pii: S1053-8119(21)00578-4
doi: 10.1016/j.neuroimage.2021.118302
pii:
doi:

Substances chimiques

1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one 0
Amyloid beta-Peptides 0
Carbon Radioisotopes 0
Carbon-11 0
Membrane Glycoproteins 0
Nerve Tissue Proteins 0
Peptide Fragments 0
Pyridines 0
Pyrrolidinones 0
Radiopharmaceuticals 0
Sv2a protein, mouse 0
amyloid beta-protein (1-40) 0
amyloid beta-protein (1-42) 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

118302

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Auteurs

Mengfei Xiong (M)

Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala SE-751 85, Sweden.

Sahar Roshanbin (S)

Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala SE-751 85, Sweden.

Johanna Rokka (J)

Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala SE-751 85, Sweden.

Eva Schlein (E)

Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala SE-751 85, Sweden.

Martin Ingelsson (M)

Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala SE-751 85, Sweden.

Dag Sehlin (D)

Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala SE-751 85, Sweden.

Jonas Eriksson (J)

Department of Medicinal Chemistry, Uppsala University, Uppsala SE-751 23, Sweden; PET Centre, Uppsala University Hospital, Uppsala SE-751 85, Sweden.

Stina Syvänen (S)

Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala SE-751 85, Sweden. Electronic address: stina.syvanen@pubcare.uu.se.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › In vivo imaging of synaptic density with [
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › In vivo imaging of synaptic density with [
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › In vivo imaging of synaptic density with [
questionsmedicales.fr › Eucaryotes › Animaux › In vivo imaging of synaptic density with [
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › In vivo imaging of synaptic density with [
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › In vivo imaging of synaptic density with [
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › In vivo imaging of synaptic density with [
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › In vivo imaging of synaptic density with [
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › In vivo imaging of synaptic density with [
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › In vivo imaging of synaptic density with [
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › In vivo imaging of synaptic density with [
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › In vivo imaging of synaptic density with [
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › In vivo imaging of synaptic density with [
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › In vivo imaging of synaptic density with [
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › In vivo imaging of synaptic density with [
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › In vivo imaging of synaptic density with [
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › In vivo imaging of synaptic density with [
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › In vivo imaging of synaptic density with [
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Pyrrolidones › In vivo imaging of synaptic density with [
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › In vivo imaging of synaptic density with [
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules de sécrétion › Vésicules synaptiques › In vivo imaging of synaptic density with [
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Synucléinopathies › In vivo imaging of synaptic density with [