Catalase, a therapeutic target in the reversal of estrogen-mediated aging.

Adipose Tissue Aging Animals Catalase / genetics Estrogens / metabolism Female Humans Mesenchymal Stem Cells / metabolism Mice
aging catalase estrogen estrogen receptor mesenchymal stem cells

Journal

Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581

Informations de publication

Date de publication:
02 02 2022
Historique:
received: 20 07 2020
revised: 30 01 2021
accepted: 09 06 2021
pubmed: 27 6 2021
medline: 8 4 2022
entrez: 26 6 2021
Statut: ppublish

Résumé

Despite increasing interest in the reversal of age-related processes, there is a paucity of data regarding the effects of post-menopausal-associated estrogen loss on cellular function. We studied human adipose-derived mesenchymal stem cells (hASCs) isolated from women younger than 45 years old (pre-menopause, pre-hASC) or older than 55 years old (post-menopause, post-hASC). In this study, we provide proof of concept that the age-related ineffective functionality of ASCs can be reversed to improve their ability in promoting tissue repair. We found reduced estrogen receptor expression, decreased estrogen receptor activation, and reduced sensitivity to 17β-estradiol in post-hASCs. This correlated with decreased antioxidants (catalase and superoxide dismutase [SOD] expression) and increased oxidative stress compared with pre-hASCs. Increasing catalase expression in post-hASCs restored estrogen receptor (ER) expression and their functional capacity to promote tissue repair as shown in human skin ex vivo wound healing and in vivo mouse model of lung injury. Our results suggest that the consequences of 17β-estradiol decline on the function of hASCs may be reversible by changing the oxidative stress/antioxidant composition.

Identifiants

DOI: 10.1016/j.ymthe.2021.06.020 PMID: 34174444 PMC: PMC8821897
pubmed: 34174444
pii: S1525-0016(21)00326-9
doi: 10.1016/j.ymthe.2021.06.020
pmc: PMC8821897
pii:
doi:

Substances chimiques

Estrogens 0
Catalase EC 1.11.1.6

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

947-962

Subventions

Organisme : NIA NIH HHS
ID : R21 AG060338
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073614
Pays : United States
Organisme : NIDDK NIH HHS
ID : RC1 DK086364
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK119085
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK115255
Pays : United States

Informations de copyright

Copyright © 2021 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Sharon J Elliot (SJ)

DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA. Electronic address: selliot@med.miami.edu.

Paola Catanuto (P)

DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

Simone Pereira-Simon (S)

DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

Xiaomei Xia (X)

Department of Medicine, Division of Pulmonary, Critical Care, and Sleep, University of Arizona College of Medicine, Phoenix, AZ 85004, USA.

Irena Pastar (I)

Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

Seth Thaller (S)

DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

Cheyanne R Head (CR)

Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

Olivera Stojadinovic (O)

Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

Marjana Tomic-Canic (M)

Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA.

Marilyn K Glassberg (MK)

DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep, University of Arizona College of Medicine, Phoenix, AZ 85004, USA. Electronic address: mglassbe@email.arizona.edu.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Catalase, a therapeutic target in the reversal...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Catalase, a therapeutic target in the reversal...
questionsmedicales.fr › Eucaryotes › Animaux › Catalase, a therapeutic target in the reversal...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Catalase › Catalase, a therapeutic target in the reversal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › Catalase, a therapeutic target in the reversal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Catalase, a therapeutic target in the reversal...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Catalase, a therapeutic target in the reversal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Catalase, a therapeutic target in the reversal...