Positive and negative roles of lipids in mast cells and allergic responses.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
31
12
2020
revised:
15
03
2021
accepted:
03
06
2021
pubmed:
27
6
2021
medline:
11
3
2022
entrez:
26
6
2021
Statut:
ppublish
Résumé
Mast cells are a central immune cell population that are crucial in allergic responses. They secrete granule contents and cytokines and produce a panel of lipid mediators in response to FcεRI-dependent or independent stimuli. Leukotrienes and prostaglandins derived from ω6 arachidonic acid, or specialized pro-resolving lipid mediators derived from ω3 eicosapentaenoic and docosahexaenoic acids, exert pleiotropic effects on various cells in the tissue microenvironment, thereby positively or negatively regulating allergic responses. Mast cells also express the inhibitory receptors CD300a and CD300f, which recognize structural lipids. CD300a or CD300f binding to externalized phosphatidylserine or extracellular ceramides, respectively, inhibits FcεRI-mediated mast cell activation. The inhibitory CD300-lipid axis downregulates IgE-driven, mast cell-dependent type I hypersensitivity through different mechanisms. Herein, we provide an overview of our current understanding of the biological roles of lipids in mast cell-dependent allergic responses.
Identifiants
pubmed: 34174696
pii: S0952-7915(21)00069-8
doi: 10.1016/j.coi.2021.06.001
pii:
doi:
Substances chimiques
Allergens
0
Biomarkers
0
Inflammation Mediators
0
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-195Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.