Presence of gustatory and olfactory dysfunction in the time of the COVID-19 pandemic.
Adolescent
Adult
Aged
Aged, 80 and over
COVID-19
/ epidemiology
Cough
/ epidemiology
Early Diagnosis
Fatigue
/ epidemiology
Female
Germany
/ epidemiology
Headache
/ epidemiology
Humans
Male
Middle Aged
Olfaction Disorders
/ diagnosis
Pandemics
Reproducibility of Results
SARS-CoV-2
/ pathogenicity
Sex Characteristics
Smell
Surveys and Questionnaires
Taste Disorders
/ epidemiology
Young Adult
Anosmia
COVID
COVID-19
COVID-19 negative Dysgeusia
Gustatory
Hyposmia
Loss
Olfaction
Olfactory
SARS-CoV-2
Smell
Taste
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
26 Jun 2021
26 Jun 2021
Historique:
received:
14
02
2021
accepted:
03
06
2021
entrez:
27
6
2021
pubmed:
28
6
2021
medline:
1
7
2021
Statut:
epublish
Résumé
The unexpected outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused more than 49 million cases and an estimated 2,000,000 associated deaths worldwide. In Germany, there are currently more than 2,000,000 laboratory-confirmed coronavirus disease 2019 (COVID-19) cases including 51,800 deaths. However, regional differences also became apparent and with the second wave of infections, the detailed characterization of COVID-19 patients is crucial to early diagnosis and disruption of chains of infections. Handing out detailed questionnaires to all individuals tested for COVID-19, we evaluated the clinical characteristics of negative and positive tested individuals. Expression of symptoms, symptom duration and association between predictor variables (i.e. age, gender) and a binary outcome (olfactory and gustatory dysfunction) were assessed. Overall, the most common symptoms among individuals who tested positive for SARS-CoV-2 were fatigue, headache, and cough. Olfactory and gustatory dysfunction were also reported by many SARS-CoV-2 negative individuals, more than 20% of SARS-CoV-2 negative tested individuals in our study reported olfactory and gustatory dysfunction. Independent of SARS-CoV-2 status, more females displayed symptoms of gustatory (29.8%, p = 0.0041) and olfactory dysfunction (22.9%, p = 0.0174) compared to men. Bringing early SARS-CoV-2 tests to the populations at risk must be a main focus for the upcoming months. The reliability of olfactory and gustatory dysfunction in COVID-19 negative tested individuals requires deeper investigation in the future.
Sections du résumé
BACKGROUND
BACKGROUND
The unexpected outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused more than 49 million cases and an estimated 2,000,000 associated deaths worldwide. In Germany, there are currently more than 2,000,000 laboratory-confirmed coronavirus disease 2019 (COVID-19) cases including 51,800 deaths. However, regional differences also became apparent and with the second wave of infections, the detailed characterization of COVID-19 patients is crucial to early diagnosis and disruption of chains of infections.
METHODS
METHODS
Handing out detailed questionnaires to all individuals tested for COVID-19, we evaluated the clinical characteristics of negative and positive tested individuals. Expression of symptoms, symptom duration and association between predictor variables (i.e. age, gender) and a binary outcome (olfactory and gustatory dysfunction) were assessed.
RESULTS
RESULTS
Overall, the most common symptoms among individuals who tested positive for SARS-CoV-2 were fatigue, headache, and cough. Olfactory and gustatory dysfunction were also reported by many SARS-CoV-2 negative individuals, more than 20% of SARS-CoV-2 negative tested individuals in our study reported olfactory and gustatory dysfunction. Independent of SARS-CoV-2 status, more females displayed symptoms of gustatory (29.8%, p = 0.0041) and olfactory dysfunction (22.9%, p = 0.0174) compared to men.
CONCLUSIONS
CONCLUSIONS
Bringing early SARS-CoV-2 tests to the populations at risk must be a main focus for the upcoming months. The reliability of olfactory and gustatory dysfunction in COVID-19 negative tested individuals requires deeper investigation in the future.
Identifiants
pubmed: 34174816
doi: 10.1186/s12879-021-06294-2
pii: 10.1186/s12879-021-06294-2
pmc: PMC8234756
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
612Subventions
Organisme : NIEHS NIH HHS
ID : 27307C0012
Pays : United States
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