Erythropoietin monotherapy for neuroprotection after neonatal encephalopathy in low-to-middle income countries: a systematic review and meta-analysis.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
04
02
2021
accepted:
04
06
2021
revised:
21
05
2021
pubmed:
28
6
2021
medline:
21
10
2021
entrez:
27
6
2021
Statut:
ppublish
Résumé
We examined whether erythropoietin monotherapy improves neurodevelopmental outcomes in near-term and term infants with neonatal encephalopathy (NE) in low-middle income countries (LMICs). We searched Pubmed, Embase, and Web of Science databases to identify studies that used erythropoietin (1500-12,500 units/kg/dose) or a derivative to treat NE. Five studies, with a total of 348 infants in LMICs, were retrieved. However, only three of the five studies met the primary outcome of death or neuro-disability at 18 months of age or later. Erythropoietin reduced the risk of death (during the neonatal period and at follow-up) or neuro-disability at 18 months or later (p < 0.05). Death or neuro-disability occurred in 27.6% of the erythropoietin group and 49.7% of the comparison group (risk ratio 0.56 (95% CI: 0.42-0.75)). The pooled data suggest that erythropoietin monotherapy may improve outcomes after NE in LMICs where therapeutic hypothermia is not available.
Identifiants
pubmed: 34175900
doi: 10.1038/s41372-021-01132-4
pii: 10.1038/s41372-021-01132-4
pmc: PMC8440196
doi:
Substances chimiques
Erythropoietin
11096-26-7
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2134-2140Subventions
Organisme : Medical Research Council
ID : MR/R001375/1
Pays : United Kingdom
Organisme : DH | National Institute for Health Research (NIHR)
ID : NIHR300118
Informations de copyright
© 2021. The Author(s).
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