Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.
Arginine methylation (ArgMe)
Asymmetric dimethylarginine (ADMA)
Biomarker
Cardiovascular disease (CVD)
Hair
Post-translational modifications (PTM)
Protein
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
27
01
2021
accepted:
17
06
2021
pubmed:
29
6
2021
medline:
21
5
2022
entrez:
28
6
2021
Statut:
ppublish
Résumé
Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily available hair samples. Here we show, first, that human hair proteins are post-translationally modified by arginine methylation (ArgMe). Using western blot, proteomic data mining and mass spectrometry, we identify several ArgMe events in hair proteins and we show that keratin-83 is extensively modified by ArgMe in the human hair. Second, using a preliminary cohort (n = 18) of heterogenous healthy donors, we show that the levels of protein ArgMe in hair correlate with serum concentrations of a well-established cardiovascular biomarker, asymmetric dimethylarginine (ADMA). Compared to blood collection, hair sampling is cheaper, simpler, requires minimal training and carries less health and safety and ethical risks. For these reasons, developing the potential of hair protein ArgMe as clinically useful cardiovascular biomarkers through further research could be useful in future prevention and diagnosis of cardiovascular disease.
Identifiants
pubmed: 34181092
doi: 10.1007/s00726-021-03024-5
pii: 10.1007/s00726-021-03024-5
pmc: PMC9117359
doi:
Substances chimiques
Biomarkers
0
Arginine
94ZLA3W45F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
591-600Subventions
Organisme : University of Hull (GB)
ID : Biomarkers Research Cluster
Organisme : Higher Education Funding Council for England
ID : HEIF
Informations de copyright
© 2021. The Author(s).
Références
Lancet. 2021 Jan 9;397(10269):129-170
pubmed: 33278353
Amino Acids. 2021 Apr;53(4):541-554
pubmed: 33651245
Eur J Endocrinol. 2015 Oct;173(4):M1-10
pubmed: 25924811
Curr Pharm Des. 2021;27(18):2131-2140
pubmed: 33413061
Trends Mol Med. 2019 Nov;25(11):993-1009
pubmed: 31230909
Nat Commun. 2020 Jul 30;11(1):3820
pubmed: 32732919
Exp Eye Res. 2009 Dec;89(6):1028-34
pubmed: 19748504
Int J Mol Sci. 2019 Sep 17;20(18):
pubmed: 31533264
Arterioscler Thromb Vasc Biol. 2008 May;28(5):961-7
pubmed: 18292394
Histochem Cell Biol. 2008 Jun;129(6):705-33
pubmed: 18461349
J Clin Med. 2020 Jun 12;9(6):
pubmed: 32545708
J Biol Regul Homeost Agents. 2014 Oct-Dec;28(4):605-14
pubmed: 25620171
Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1540-6
pubmed: 21493890
Atherosclerosis. 2001 Oct;158(2):425-30
pubmed: 11583722
Proteomics Clin Appl. 2018 Mar;12(2):
pubmed: 28960873
BMC Pulm Med. 2009 Jan 29;9:5
pubmed: 19178698
Amino Acids. 2016 Mar;48(3):641-651
pubmed: 26503606
Circulation. 1997 Apr 15;95(8):2068-74
pubmed: 9133517
Sci Rep. 2018 Jan 25;8(1):1599
pubmed: 29371649
Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E1070-E1080
pubmed: 31593503
Amino Acids. 2021 Apr;53(4):489-506
pubmed: 33404912
Gene. 2017 May 30;614:15-20
pubmed: 28284878
J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Mar 15;1141:122024
pubmed: 32062367
J Clin Med. 2020 Dec 01;9(12):
pubmed: 33271854
Exp Dermatol. 2015 Mar;24(3):222-4
pubmed: 25557232
Cardiovasc Drugs Ther. 2006 Aug;20(4):281-94
pubmed: 16897158
Amino Acids. 2015 Sep;47(9):1893-908
pubmed: 26031828
Atheroscler Suppl. 2019 Dec;40:100-105
pubmed: 31818438
Curr Cardiol Rep. 2019 Aug 30;21(10):116
pubmed: 31471749
Vasc Health Risk Manag. 2005;1(4):291-9
pubmed: 17315601
Clin Chim Acta. 2003 Oct;336(1-2):1-12
pubmed: 14500028
Nat Med. 2007 Feb;13(2):198-203
pubmed: 17273169
Endocrinol Metab Clin North Am. 2014 Mar;43(1):75-102
pubmed: 24582093
Allergy Asthma Clin Immunol. 2018 Jan 03;14:2
pubmed: 29308071
Adv Exp Med Biol. 2020;1249:223-229
pubmed: 32602100
Nutrients. 2019 Jun 27;11(7):
pubmed: 31252632
Forensic Sci Int Genet. 2020 Jul;47:102309
pubmed: 32485593
PLoS One. 2018 Aug 16;13(8):e0202608
pubmed: 30114294
Circulation. 2020 Mar 3;141(9):e139-e596
pubmed: 31992061
Sci Rep. 2020 Dec 17;10(1):22155
pubmed: 33335114
Eur Heart J. 2005 Sep;26(18):1846-51
pubmed: 15860520
Acta Pharmacol Sin. 2018 Jul;39(7):1068-1072
pubmed: 29645001
J Clin Endocrinol Metab. 2013 May;98(5):2078-83
pubmed: 23596141
J Cardiovasc Pharmacol. 1999 Apr;33(4):652-8
pubmed: 10218738
Proteomics Clin Appl. 2017 Jan;11(1-2):
pubmed: 27600370
Amino Acids. 2013 Dec;45(6):1405-13
pubmed: 24178767
Clin Chem. 2007 Feb;53(2):273-83
pubmed: 17185364
J Clin Med. 2020 Dec 08;9(12):
pubmed: 33302555
Hypertens Res. 2021 Jan;44(1):71-79
pubmed: 32681162
Circ Res. 2000 Jul 21;87(2):99-105
pubmed: 10903992
Stroke. 2008 Jan;39(1):180-4
pubmed: 18063827
Psychoneuroendocrinology. 2012 May;37(5):589-601
pubmed: 21974976
Am J Pathol. 2010 May;176(5):2559-70
pubmed: 20348244
Amino Acids. 2019 Jun;51(6):913-927
pubmed: 30915571
Amino Acids. 2018 Sep;50(9):1169-1176
pubmed: 29951704
J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021
pubmed: 33309175
J Biol Chem. 2012 Mar 9;287(11):7859-70
pubmed: 22241471
Stress. 2011 Jan;14(1):73-81
pubmed: 20812871