Highly modified nor-clerodane diterpenoids from Croton yanhuii.
Croton yanhuii
Euphorbiaceae
Single-crystal X-ray diffraction
nor-clerodane diterpenoids
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
30
05
2021
revised:
21
06
2021
accepted:
23
06
2021
pubmed:
29
6
2021
medline:
18
9
2021
entrez:
28
6
2021
Statut:
ppublish
Résumé
Phytochemical investigation of the leaves and twigs of Croton yanhuii led to the isolation of seven highly modified nor-clerodane diterpenoids (1-7), including three new ones, croyanoids A-C (1-3), along with four known analogues (4-7). Compound 1 incorporates a 5,12-epoxy ring, forming a unique cage-like, 6/6/6/5-fused tetracyclic ring system. Their structures were established by extensive spectroscopic analysis, and the absolute configurations of 1-4 were determined by a combination of circular dichroism (CD) analysis and single-crystal X-ray diffraction. All compounds were tested in an array of bioassays, but were inactive. Crotoeurin A (7), a nor-clerodane dimer with a high yield of 0.2‰ isolated in current study, was considered as a chemotaxonomic marker for this species.
Identifiants
pubmed: 34182053
pii: S0367-326X(21)00154-4
doi: 10.1016/j.fitote.2021.104979
pii:
doi:
Substances chimiques
Diterpenes, Clerodane
0
Phytochemicals
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104979Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.