Effect of IL8 haplotype on immunological traits in periparturient dairy cows.

Animals Antigens, CD / genetics Cattle / genetics Female Gene Expression Regulation Homozygote Interleukin-8 / genetics Peripartum Period / blood
Haplotype IL8 Immunological traits T lymphocytes d-ROMs

Journal

Veterinary immunology and immunopathology
ISSN: 1873-2534
Titre abrégé: Vet Immunol Immunopathol
Pays: Netherlands
ID NLM: 8002006

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 28 01 2021
revised: 15 06 2021
accepted: 17 06 2021
pubmed: 29 6 2021
medline: 16 11 2021
entrez: 28 6 2021
Statut: ppublish

Résumé

Interleukin 8 (IL8) is a major mediator of the innate immune response. Polymorphisms in this gene are associated with susceptibility to inflammatory disease in humans. Two major promoter polymorphic haplotypes (IL8-h1 and IL8-h2) segregating in cattle populations have shown a significant effect on the immune response profile in calves but their implications for transition cow immunity have not been established. The aims of this study were to assess functional relevance of the IL8 haplotypes on the immunological traits of periparturient cows (n = 32) belonging to three genetic groups: Holstein (HO), Simmental (SI) and their crosses (CR) and to evaluate the frequency of IL8 haplotypes in the HO (dairy) and SI (dual purpose) pure breeds. IL8 haplotypes showed a significant effect on circulating number of both T helper lymphocytes (P = 0.0133) and T cytotoxic lymphocytes (P = 0.0024). Differences in percentage of CD14

Identifiants

DOI: 10.1016/j.vetimm.2021.110288 PMID: 34182229
pubmed: 34182229
pii: S0165-2427(21)00106-9
doi: 10.1016/j.vetimm.2021.110288
pii:
doi:

Substances chimiques

Antigens, CD 0
Interleukin-8 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110288

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Giovanna De Matteis (G)

Research Centre for Animal Production and Aquaculture, Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria (CREA), Via Salaria, 31-Monterotondo, Rome, Italy. Electronic address: giovanna.dematteis@crea.gov.it.

Maria Carmela Scatà (MC)

Research Centre for Animal Production and Aquaculture, Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria (CREA), Via Salaria, 31-Monterotondo, Rome, Italy.

Francesco Grandoni (F)

Research Centre for Animal Production and Aquaculture, Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria (CREA), Via Salaria, 31-Monterotondo, Rome, Italy.

Alessandra Crisà (A)

Research Centre for Animal Production and Aquaculture, Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria (CREA), Via Salaria, 31-Monterotondo, Rome, Italy.

Megan B O'Brien (MB)

Animal & Bioscience Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Grange, Co Meath, Ireland; School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland.

Kieran G Meade (KG)

School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland.

Gennaro Catillo (G)

Research Centre for Animal Production and Aquaculture, Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria (CREA), Via Salaria, 31-Monterotondo, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Effect of IL8 haplotype on immunological...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Effect of IL8 haplotype on immunological...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Effect of IL8 haplotype on immunological...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Effect of IL8 haplotype on immunological...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Homozygote › Effect of IL8 haplotype on immunological...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-8 › Effect of IL8 haplotype on immunological...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Période de péripartum › Effect of IL8 haplotype on immunological...