Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant

Acyl Coenzyme A / analysis Anti-Bacterial Agents / pharmacology Gene Expression Regulation, Bacterial Methicillin-Resistant Staphylococcus aureus / drug effects Microbial Sensitivity Tests Mutation Proteome beta-Lactam Resistance beta-Lactams / pharmacology
MRSA TCA cycle antibiotic resistance beta-lactams succinyl-CoA succinylome

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
29 06 2021
Historique:
pubmed: 30 6 2021
medline: 16 11 2021
entrez: 29 6 2021
Statut: ppublish

Résumé

Penicillin binding protein 2a (PBP2a)-dependent resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is regulated by the activity of the tricarboxylic acid (TCA) cycle via a poorly understood mechanism. We report that mutations in

Identifiants

DOI: 10.1128/mBio.00530-21 PMID: 34182779 PMC: PMC8437408
pubmed: 34182779
doi: 10.1128/mBio.00530-21
pmc: PMC8437408
doi:

Substances chimiques

Acyl Coenzyme A 0
Anti-Bacterial Agents 0
Proteome 0
beta-Lactams 0
succinyl-coenzyme A BSI27HW5EQ

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0053021

Subventions

Organisme : NIAID NIH HHS
ID : P01 AI083211
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103493
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125588
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125589
Pays : United States

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Auteurs

Christopher Campbell (C)

Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.

Claire Fingleton (C)

Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.

Merve S Zeden (MS)

Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.

Emilio Bueno (E)

MIMS-Molecular Infection Medicine Sweden, Molecular Biology Department, Umeå University, Umeå, Sweden.

Laura A Gallagher (LA)

Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.

Dhananjay Shinde (D)

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Jongsam Ahn (J)

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Heather M Olson (HM)

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.

Thomas L Fillmore (TL)

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.

Joshua N Adkins (JN)

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.

Fareha Razvi (F)

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Kenneth W Bayles (KW)

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Paul D Fey (PD)

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Vinai C Thomas (VC)

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Felipe Cava (F)

MIMS-Molecular Infection Medicine Sweden, Molecular Biology Department, Umeå University, Umeå, Sweden.

Geremy C Clair (GC)

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA.

James P O'Gara (JP)

Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Acyl coenzyme A › Accumulation of Succinyl Coenzyme A Perturbs...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Accumulation of Succinyl Coenzyme A Perturbs...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › Accumulation of Succinyl Coenzyme A Perturbs...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Accumulation of Succinyl Coenzyme A Perturbs...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Accumulation of Succinyl Coenzyme A Perturbs...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Accumulation of Succinyl Coenzyme A Perturbs...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Accumulation of Succinyl Coenzyme A Perturbs...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Résistance aux bêta-lactamines › Accumulation of Succinyl Coenzyme A Perturbs...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Accumulation of Succinyl Coenzyme A Perturbs...