Stage dependent recurrence patterns and post-recurrence outcomes in non-metastatic colon cancer.

Cohort Studies Colonic Neoplasms / surgery Colorectal Neoplasms / pathology Humans Neoplasm Recurrence, Local / epidemiology Neoplasm Staging Retrospective Studies Survival Rate
Colorectal cancer staging surveillance survival

Journal

Acta oncologica (Stockholm, Sweden)
ISSN: 1651-226X
Titre abrégé: Acta Oncol
Pays: England
ID NLM: 8709065

Informations de publication

Date de publication:
Sep 2021
Historique:
pubmed: 30 6 2021
medline: 25 8 2021
entrez: 29 6 2021
Statut: ppublish

Résumé

Multiple meta-analyses have demonstrated that routine surveillance following colorectal cancer surgery improves survival outcomes. There is limited data on how recurrence patterns and post-recurrence outcomes vary by individual tumor stage. Using a multi-site community cohort study, we examined the potential impact of primary tumor stage on the sites of recurrence, management of recurrent disease with curative intent, and post-resection survival. We also explored changes over time. Of 4257 new colon cancers diagnosed 2001 through 2016, 789 (21.1%) had stage I, 1584 (42.4%) had stage II, and 1360 (36.4%) had stage III colon cancer. For consecutive 5-year periods (2001-2005, 2006-2010, 2011-2016), recurrence rates have declined (23.4 In this community cohort we defined significant differences in recurrence patterns and post-resection survival by tumor stage, with a diminishing rate of recurrence over time. While recurrence rates were lower with stage I and II disease, the high rate of metastatic disease resection and excellent post-resection outcomes help to justify routine surveillance in these patients.

Sections du résumé

BACKGROUND BACKGROUND
Multiple meta-analyses have demonstrated that routine surveillance following colorectal cancer surgery improves survival outcomes. There is limited data on how recurrence patterns and post-recurrence outcomes vary by individual tumor stage.
METHODS METHODS
Using a multi-site community cohort study, we examined the potential impact of primary tumor stage on the sites of recurrence, management of recurrent disease with curative intent, and post-resection survival. We also explored changes over time.
RESULTS RESULTS
Of 4257 new colon cancers diagnosed 2001 through 2016, 789 (21.1%) had stage I, 1584 (42.4%) had stage II, and 1360 (36.4%) had stage III colon cancer. For consecutive 5-year periods (2001-2005, 2006-2010, 2011-2016), recurrence rates have declined (23.4
CONCLUSION CONCLUSIONS
In this community cohort we defined significant differences in recurrence patterns and post-resection survival by tumor stage, with a diminishing rate of recurrence over time. While recurrence rates were lower with stage I and II disease, the high rate of metastatic disease resection and excellent post-resection outcomes help to justify routine surveillance in these patients.

Identifiants

DOI: 10.1080/0284186X.2021.1943519 PMID: 34184594
pubmed: 34184594
doi: 10.1080/0284186X.2021.1943519
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1106-1113

Auteurs

Lucy Gately (L)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Australia.
ORCID: 0000-0002-3003-3175

Azim Jalali (A)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Australia.
Department of Medical Oncology, Western Health Medical School, University of Melbourne, Footscray, Australia.

Christine Semira (C)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.

Ian Faragher (I)

Department of Surgery, Western Health Medical School, University of Melbourne, Footscray, Australia.

Matthew Croxford (M)

Department of Surgery, Western Health Medical School, University of Melbourne, Footscray, Australia.

Sumitra Ananda (S)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Australia.
Department of Medical Oncology, Western Health Medical School, University of Melbourne, Footscray, Australia.
Department of Oncology, Peter MacCallum Cancer Centre, Parkville, Australia.
Epworth Freemasons, East Melbourne, Australia.

Suzanne Kosmider (S)

Department of Medical Oncology, Western Health Medical School, University of Melbourne, Footscray, Australia.

Kathryn Field (K)

Department of Medical Oncology, Royal Melbourne Hospital, Parkville, Australia.

Sheau Wen Lok (SW)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Australia.
Department of Oncology, Peter MacCallum Cancer Centre, Parkville, Australia.

Grace Gard (G)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.

Malcolm Steel (M)

Department of Surgical Oncology, Eastern Health, Box Hill, Australia.

Margaret Lee (M)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Australia.
Department of Medical Oncology, Eastern Health, Box Hill, Australia.

Rachel Wong (R)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Oncology, Eastern Health, Box Hill, Australia.
Eastern Health Clinical School, Monash University, Box Hill, Australia.

Hui-Li Wong (HL)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Australia.
Department of Oncology, Peter MacCallum Cancer Centre, Parkville, Australia.

Peter Gibbs (P)

Personalised Oncology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Australia.
Department of Medical Oncology, Western Health Medical School, University of Melbourne, Footscray, Australia.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Stage dependent recurrence patterns and...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Stage dependent recurrence patterns and...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Stage dependent recurrence patterns and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Stage dependent recurrence patterns and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Stage dependent recurrence patterns and...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Stage dependent recurrence patterns and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Stage dependent recurrence patterns and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Taux de survie › Stage dependent recurrence patterns and...