R2* and quantitative susceptibility mapping in deep gray matter of 498 healthy controls from 5 to 90 years.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Biological Variation, Individual
Child
Child, Preschool
Corpus Striatum
/ anatomy & histology
Female
Gray Matter
/ anatomy & histology
Human Development
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Thalamus
/ anatomy & histology
Young Adult
R2*
aging
brain iron
deep gray matter
development
lifespan
susceptibility
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
revised:
08
06
2021
received:
01
05
2021
accepted:
11
06
2021
pubmed:
30
6
2021
medline:
19
3
2022
entrez:
29
6
2021
Statut:
ppublish
Résumé
Putative MRI markers of iron in deep gray matter have demonstrated age related changes during discrete periods of healthy childhood or adulthood, but few studies have included subjects across the lifespan. This study reports both transverse relaxation rate (R2*) and quantitative susceptibility mapping (QSM) of four primary deep gray matter regions (thalamus, putamen, caudate, and globus pallidus) in 498 healthy individuals aged 5-90 years. In the caudate, putamen, and globus pallidus, increases of QSM and R2* were steepest during childhood continuing gradually throughout adulthood, except caudate susceptibility which reached a plateau in the late 30s. The thalamus had a unique profile with steeper changes of R2* (reflecting additive effects of myelin and iron) than QSM during childhood, both reaching a plateau in the mid-30s to early 40s and decreasing thereafter. There were no hemispheric or sex differences for any region. Notably, both R2* and QSM values showed more inter-subject variability with increasing age from 5 to 90 years, potentially reflecting a common starting point in iron/myelination during childhood that diverges as a result of lifestyle and genetic factors that accumulate with age.
Identifiants
pubmed: 34184808
doi: 10.1002/hbm.25569
pmc: PMC8410539
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4597-4610Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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