Effect of bariatric surgery on endogenous sex hormones and sex hormone-binding globulin levels: a systematic review and meta-analysis.
Bariatric surgery
Obesity
Sex hormones
Sexual function
Weight loss
Journal
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
ISSN: 1878-7533
Titre abrégé: Surg Obes Relat Dis
Pays: United States
ID NLM: 101233161
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
22
06
2020
revised:
14
04
2021
accepted:
06
05
2021
pubmed:
1
7
2021
medline:
28
8
2021
entrez:
30
6
2021
Statut:
ppublish
Résumé
Most studies have shown beneficial effect of bariatric surgery (BS) on serum levels of sex hormones. A systematic review and meta-analysis was conducted to examine the magnitude of possible changes in levels of sex hormones following BS. Electronic databases were searched, including PubMed, Scopus, Web of Science, and Embase, for relevant studies. The heterogeneity of the studies was examined by χ The results of pooled analyses revealed that BS caused a significant increase in luteinizing hormone (LH), follicular stimulating hormone (FSH), total testosterone (TT), and sex hormone binding globulin (SHBG) levels and conversely, decreased dehydroepiandrosterone (DHEA) and estradiol (E2) levels in males. For females, BS significantly increased LH, FSH, and SHBG levels and conversely, decreased androstenedione (AE), E2 and TT levels. Additionally, the level of progesterone (P), prolactin (PRL), free testosterone (FT) and dehydroepiandrosterone sulfate (DHEA-S) showed no significant changes in patients who had undergone BS. BS changed most sex hormones levels including LH, FSH, TT, SHBG, AE, DHEA, and E2. It seems that BS is able to exert substantial impacts on sex hormones levels and as well as sexual function, however, larger, and more precise trials are required to specifically focus on these claims.
Sections du résumé
BACKGROUND
BACKGROUND
Most studies have shown beneficial effect of bariatric surgery (BS) on serum levels of sex hormones.
OBJECTIVE
OBJECTIVE
A systematic review and meta-analysis was conducted to examine the magnitude of possible changes in levels of sex hormones following BS.
SETTINGS
METHODS
Electronic databases were searched, including PubMed, Scopus, Web of Science, and Embase, for relevant studies.
METHODS
METHODS
The heterogeneity of the studies was examined by χ
RESULTS
RESULTS
The results of pooled analyses revealed that BS caused a significant increase in luteinizing hormone (LH), follicular stimulating hormone (FSH), total testosterone (TT), and sex hormone binding globulin (SHBG) levels and conversely, decreased dehydroepiandrosterone (DHEA) and estradiol (E2) levels in males. For females, BS significantly increased LH, FSH, and SHBG levels and conversely, decreased androstenedione (AE), E2 and TT levels. Additionally, the level of progesterone (P), prolactin (PRL), free testosterone (FT) and dehydroepiandrosterone sulfate (DHEA-S) showed no significant changes in patients who had undergone BS.
CONCLUSION
CONCLUSIONS
BS changed most sex hormones levels including LH, FSH, TT, SHBG, AE, DHEA, and E2. It seems that BS is able to exert substantial impacts on sex hormones levels and as well as sexual function, however, larger, and more precise trials are required to specifically focus on these claims.
Identifiants
pubmed: 34187743
pii: S1550-7289(21)00236-7
doi: 10.1016/j.soard.2021.05.003
pii:
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Sex Hormone-Binding Globulin
0
Luteinizing Hormone
9002-67-9
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1621-1636Informations de copyright
Copyright © 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.