Allosteric drug transport mechanism of multidrug transporter AcrB.
Allosteric Site
Anti-Bacterial Agents
/ chemistry
Binding Sites
Cell Membrane
/ metabolism
Drug Resistance, Multiple, Bacterial
Escherichia coli
/ chemistry
Escherichia coli Proteins
/ chemistry
Models, Molecular
Multidrug Resistance-Associated Proteins
/ chemistry
Mutation
Protein Conformation
Protein Domains
Substrate Specificity
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 06 2021
29 06 2021
Historique:
received:
22
04
2021
accepted:
02
06
2021
entrez:
30
6
2021
pubmed:
1
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Gram-negative bacteria maintain an intrinsic resistance mechanism against entry of noxious compounds by utilizing highly efficient efflux pumps. The E. coli AcrAB-TolC drug efflux pump contains the inner membrane H
Identifiants
pubmed: 34188038
doi: 10.1038/s41467-021-24151-3
pii: 10.1038/s41467-021-24151-3
pmc: PMC8242077
doi:
Substances chimiques
AcrB protein, E coli
0
Anti-Bacterial Agents
0
Escherichia coli Proteins
0
Multidrug Resistance-Associated Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3889Références
Antimicrob Agents Chemother. 2016 Jun 20;60(7):4315-23
pubmed: 27161641
Science. 2006 Sep 1;313(5791):1295-8
pubmed: 16946072
Nat Struct Mol Biol. 2008 Feb;15(2):199-205
pubmed: 18223659
Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1865-7
pubmed: 12351840
Acta Crystallogr D Struct Biol. 2017 Feb 1;73(Pt 2):148-157
pubmed: 28177311
Mol Microbiol. 2010 Oct;78(2):320-30
pubmed: 20804453
Elife. 2017 Mar 29;6:
pubmed: 28355133
Clin Microbiol Rev. 2015 Apr;28(2):337-418
pubmed: 25788514
J Mol Biol. 2020 Feb 14;432(4):861-877
pubmed: 31881208
Nature. 2013 Aug 1;500(7460):102-6
pubmed: 23812586
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5854-8
pubmed: 19307562
Nature. 2011 Nov 27;480(7378):565-9
pubmed: 22121023
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):235-42
pubmed: 21460441
Curr Top Med Chem. 2013;13(24):3079-100
pubmed: 24200360
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67
pubmed: 21460454
Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21
pubmed: 20057044
Structure. 2008 Mar;16(3):351-9
pubmed: 18334210
Ann N Y Acad Sci. 2020 Jan;1459(1):38-68
pubmed: 31588569
Nat Commun. 2016 Dec 16;7:13819
pubmed: 27982032
Biochim Biophys Acta. 2009 May;1794(5):769-81
pubmed: 19026770
mBio. 2020 May 26;11(3):
pubmed: 32457251
PLoS Comput Biol. 2012;8(10):e1002708
pubmed: 23093919
J Mol Biol. 1996 Jul 19;260(3):289-98
pubmed: 8757792
J Bacteriol. 1996 Jan;178(1):306-8
pubmed: 8550435
Nat Commun. 2018 Jan 9;9(1):124
pubmed: 29317622
Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):381-90
pubmed: 22505258
mBio. 2017 Oct 31;8(5):
pubmed: 29089426
Nature. 2002 Oct 10;419(6907):587-93
pubmed: 12374972
Methods Mol Biol. 2018;1700:3-24
pubmed: 29177822
Biochemistry. 2013 Nov 19;52(46):8342-51
pubmed: 24205856
Nature. 2006 Sep 14;443(7108):173-9
pubmed: 16915237
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
PLoS One. 2016 Jul 12;11(7):e0159154
pubmed: 27403665
Chem Rev. 2021 May 12;121(9):5479-5596
pubmed: 33909410
Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5687-92
pubmed: 22451937
Curr Drug Targets. 2008 Sep;9(9):729-49
pubmed: 18781920
PLoS Biol. 2007 Jan;5(1):e7
pubmed: 17194213
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Nat Rev Microbiol. 2018 Sep;16(9):523-539
pubmed: 30002505
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
Biochemistry. 2009 Jun 30;48(25):5801-12
pubmed: 19425588
Elife. 2014 Sep 19;3:
pubmed: 25248080