Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis.

Animals Humans Lupus Erythematosus, Systemic Mice Selectins T-Lymphocytes, Regulatory Transforming Growth Factor beta

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
30 06 2021
Historique:
received: 08 01 2020
revised: 14 03 2021
accepted: 25 05 2021
entrez: 1 7 2021
pubmed: 2 7 2021
medline: 13 7 2021
Statut: ppublish

Résumé

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of tolerance toward self-nucleic acids, autoantibody production, interferon expression and signaling, and a defect in the regulatory T (T

Identifiants

DOI: 10.1126/scitranslmed.abi4994 PMID: 34193612
pubmed: 34193612
pii: 13/600/eabi4994
doi: 10.1126/scitranslmed.abi4994
pii:
doi:

Substances chimiques

Selectins 0
Transforming Growth Factor beta 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : CommentIn
Type : ErratumIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Marc Scherlinger (M)

Department of Rheumatology, Pellegrin, Bordeaux University Hospital, 33076 Bordeaux, France.
Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.
ORCID: 0000-0002-9453-5895

Vivien Guillotin (V)

Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.
Department of Internal Medicine, Saint André, Bordeaux University Hospital, 33076 Bordeaux, France.
ORCID: 0000-0001-7547-2932

Isabelle Douchet (I)

UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.

Pierre Vacher (P)

INSERM U1218, 33076 Bordeaux, France.
ORCID: 0000-0003-3503-7981

Andréa Boizard-Moracchini (A)

UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.

Jean-Philippe Guegan (JP)

Explicyte, 229 Cours de l'Argonne, 33000 Bordeaux, France.

Anne Garreau (A)

UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.

Nathalie Merillon (N)

UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.

Agathe Vermorel (A)

Nephrology Department, Bordeaux University Hospital, 33076 Bordeaux, France.

Emmanuel Ribeiro (E)

Department of Internal Medicine, Saint André, Bordeaux University Hospital, 33076 Bordeaux, France.

Irène Machelart (I)

Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
Department of Internal Medicine, Haut-Leveque, Bordeaux University Hospital, 33604, Pessac, France.

Estibaliz Lazaro (E)

Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
Department of Internal Medicine, Haut-Leveque, Bordeaux University Hospital, 33604, Pessac, France.
ORCID: 0000-0002-4206-7399

Lionel Couzi (L)

Nephrology Department, Bordeaux University Hospital, 33076 Bordeaux, France.
ORCID: 0000-0002-9213-6196

Pierre Duffau (P)

Department of Internal Medicine, Saint André, Bordeaux University Hospital, 33076 Bordeaux, France.
ORCID: 0000-0002-4463-6583

Thomas Barnetche (T)

Department of Rheumatology, Pellegrin, Bordeaux University Hospital, 33076 Bordeaux, France.
Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
ORCID: 0000-0002-0975-8534

Jean-Luc Pellegrin (JL)

Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
Department of Internal Medicine, Haut-Leveque, Bordeaux University Hospital, 33604, Pessac, France.
ORCID: 0000-0003-4387-2282

Jean-François Viallard (JF)

Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
Department of Internal Medicine, Haut-Leveque, Bordeaux University Hospital, 33604, Pessac, France.

Maya Saleh (M)

UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.

Thierry Schaeverbeke (T)

Department of Rheumatology, Pellegrin, Bordeaux University Hospital, 33076 Bordeaux, France.
Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
ORCID: 0000-0002-6976-643X

Patrick Legembre (P)

Contrôle de la Réponse Immune B et lymphoproliférations, CRIBL, UMR CNRS 7276, INSERM 1262, Limoges, France.
ORCID: 0000-0001-6649-8049

Marie-Elise Truchetet (ME)

Department of Rheumatology, Pellegrin, Bordeaux University Hospital, 33076 Bordeaux, France.
Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.

Hélène Dumortier (H)

CNRS, UPR 3572 I2CT, IBMC, 67000 Strasbourg, France.
ORCID: 0000-0003-2356-1110

Cécile Contin-Bordes (C)

UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.
Department of Immunology and Immunogenetics, Bordeaux University Hospital, 33076 Bordeaux, France.
ORCID: 0000-0003-4652-2907

Vanja Sisirak (V)

UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.
ORCID: 0000-0003-3070-6533

Christophe Richez (C)

Department of Rheumatology, Pellegrin, Bordeaux University Hospital, 33076 Bordeaux, France. patrick.blanco@chu-bordeaux.fr christophe.richez@chu-bordeaux.fr.
Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France.
UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.
ORCID: 0000-0002-3029-8739

Patrick Blanco (P)

Centre national de référence maladie auto-immune et systémique rares Est/Sud-Ouest (RESO), Bordeaux University Hospital, 33076 Bordeaux, France. patrick.blanco@chu-bordeaux.fr christophe.richez@chu-bordeaux.fr.
UMR-CNRS 5164, ImmunoConcept, University of Bordeaux, 33076 Bordeaux, France.
Department of Immunology and Immunogenetics, Bordeaux University Hospital, 33076 Bordeaux, France.
ORCID: 0000-0002-5374-3639

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Selectins impair regulatory T cell function...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Selectins impair regulatory T cell function...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › Selectins impair regulatory T cell function...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Selectins impair regulatory T cell function...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Sélectines › Selectins impair regulatory T cell function...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Selectins impair regulatory T cell function...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Selectins impair regulatory T cell function...