Shape of promoter antisense RNAs regulates ligand-induced transcription activation.

Cell Line Chromobox Protein Homolog 5 / metabolism Crk-Associated Substrate Protein Estrogen Receptor alpha / metabolism Histones / chemistry Humans Jumonji Domain-Containing Histone Demethylases / metabolism Ligands Nucleic Acid Conformation Positive Transcriptional Elongation Factor B / metabolism Promoter Regions, Genetic / genetics RNA Polymerase II / metabolism RNA Stability RNA, Antisense / chemistry Transcriptional Activation / genetics Tripartite Motif-Containing Protein 28 / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2021
Historique:
received: 19 11 2019
accepted: 28 04 2021
pubmed: 2 7 2021
medline: 18 1 2022
entrez: 1 7 2021
Statut: ppublish

Résumé

The size of the transcriptional program of long non-coding RNAs in the mammalian genome has engendered discussions about their biological roles

Identifiants

DOI: 10.1038/s41586-021-03589-x PMID: 34194047 PMC: PMC8439151
pubmed: 34194047
doi: 10.1038/s41586-021-03589-x
pii: 10.1038/s41586-021-03589-x
pmc: PMC8439151
mid: NIHMS1725588
doi:

Substances chimiques

Bcar1 protein, mouse 0
Crk-Associated Substrate Protein 0
Estrogen Receptor alpha 0
HP1-alpha protein, human 0
Histones 0
KDM4C protein, human 0
Ligands 0
RNA, Antisense 0
Chromobox Protein Homolog 5 107283-02-3
Jumonji Domain-Containing Histone Demethylases EC 1.14.11.-
KDM4B protein, human EC 1.14.11.-
TRIM28 protein, human EC 2.3.2.27
Tripartite Motif-Containing Protein 28 EC 2.3.2.27
Positive Transcriptional Elongation Factor B EC 2.7.11.-
RNA Polymerase II EC 2.7.7.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

444-449

Subventions

Organisme : NEI NIH HHS
ID : P30 EY026877
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK039949
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL150521
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK018477
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK039949
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131780
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS093066
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Fan Yang (F)

Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA. fay009@health.ucsd.edu.
ORCID: 0000-0003-4440-6128

Bogdan Tanasa (B)

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA.

Rudi Micheletti (R)

Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.

Kenneth A Ohgi (KA)

Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.

Aneel K Aggarwal (AK)

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-4389-0173

Michael G Rosenfeld (MG)

Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA. mrosenfeld@health.ucsd.edu.
ORCID: 0000-0002-1572-156X

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Homologue-5 de la protéine chromobox › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine BCAR1 › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur alpha des oestrogènes › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Jumonji Domain-Containing Histone Demethylases › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs d'élongation transcriptionnelle › Facteur B d'élongation transcriptionnelle positive › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › DNA-directed RNA polymerases › RNA polymerase II › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité de l'ARN › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Éléments antisens (génétique) › ARN antisens › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › Shape of promoter antisense RNAs regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à motif tripartite › Protéine-28 à motif tripartite › Shape of promoter antisense RNAs regulates...