Zeta-carbonic anhydrases show CS
AAZ, Acetazolamide
CA, Carbonic Anhydrase
CAI, Carbonic Anhydrase Inhibitor
CCD, Charge Coupled Device
CDCA1, Cadmium-specific Carbonic Anhydrase
CO2
CS2
CS2H, S. solfataricus CS2 hydrolase
Cambialistic enzyme
Carbonic Anhydrase
DMSO, Dimethyl Sulfoxide
FbiCA, Flaveria bidentis Carbonic Anhydrase
HEPES, 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
IPTG, Isopropyl-β-D-1-thiogalactopyranoside
MD, Molecular Dynamics
Molecular dynamics
NCS, Non-Crystallographic Symmetry
PDB, Protein Data Bank
PEG, Polyethylene glycol
SDS-PAGE, Sodium Dodecyl Sulphate - PolyAcrylamide Gel Electrophoresis
Tris-HCl, Tris(hydroxymethyl)aminomethane hydrochloride
bCA, bovine Carbonic Anhydrase
hCA, human Carbonic Anhydrase
psCA3, Pseudomonas aeruginosa Carbonic Anhydrase 3
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
04
2021
revised:
27
05
2021
accepted:
30
05
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
2
7
2021
Statut:
epublish
Résumé
CDCA1 is a very peculiar member of the Carbonic Anhydrase (CA) family. It has been the first enzyme to show an efficient utilization of Cd(II) ions in Nature and a unique adaptation capability to live on the surface ocean. Indeed, in this environment, which is extremely depleted in essential metal ions, CDCA1 can utilize Zn(II) or Cd(II) as catalytic metal to support the metabolic needs of fast growing diatoms. In this paper we demonstrate a further catalytic versatility of this enzyme by using a combination of X-ray crystallography, molecular dynamics simulations and enzymatic experiments. First we identified the CO
Identifiants
pubmed: 34194668
doi: 10.1016/j.csbj.2021.05.057
pii: S2001-0370(21)00246-4
pmc: PMC8217695
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3427-3436Informations de copyright
© 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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