Effect of Clonally Expanded PD-1
Antibodies, Antinuclear
Arthritis, Juvenile
/ immunology
B-Lymphocytes
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
Cell Differentiation
Humans
Joints
/ cytology
Lymphocyte Activation
Programmed Cell Death 1 Receptor
/ immunology
Receptors, CXCR5
/ immunology
T-Lymphocytes, Helper-Inducer
/ immunology
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
18
05
2021
received:
18
12
2020
accepted:
29
06
2021
pubmed:
2
7
2021
medline:
19
2
2022
entrez:
1
7
2021
Statut:
ppublish
Résumé
Antinuclear antibody (ANA)-positive juvenile idiopathic arthritis (JIA) is characterized by synovial B cell hyperactivity, but the precise role of CD4+ T cells in promoting local B cell activation is unknown. This study was undertaken to determine the phenotype and function of synovial CD4+ T cells that promote aberrant B cell activation in JIA. Flow cytometry was performed to compare the phenotype and cytokine patterns of PD-1 Multidimensional flow cytometry revealed the expansion of interleukin-21 (IL-21) and interferon-γ (IFNγ)-coexpressing PD-1 Clonally expanded CD4+ Tph cells accumulate in the joints of ANA-positive JIA patients and, in particular, promote CD21
Substances chimiques
Antibodies, Antinuclear
0
CXCR5 protein, human
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
Receptors, CXCR5
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
150-162Informations de copyright
© 2021 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
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