Functions of Coronavirus Accessory Proteins: Overview of the State of the Art.
accessory protein
coronavirus
infection
innate immunity
pathogenesis
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
13 06 2021
13 06 2021
Historique:
received:
17
05
2021
revised:
11
06
2021
accepted:
11
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
16
7
2021
Statut:
epublish
Résumé
Coronavirus accessory proteins are a unique set of proteins whose genes are interspersed among or within the genes encoding structural proteins. Different coronavirus genera, or even different species within the same coronavirus genus, encode varying amounts of accessory proteins, leading to genus- or species-specificity. Though accessory proteins are dispensable for the replication of coronavirus in vitro, they play important roles in regulating innate immunity, viral proliferation, and pathogenicity. The function of accessory proteins on virus infection and pathogenesis is an area of particular interest. In this review, we summarize the current knowledge on accessory proteins of several representative coronaviruses that infect humans or animals, including the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with an emphasis on their roles in interaction between virus and host, mainly involving stress response, innate immunity, autophagy, and apoptosis. The cross-talking among these pathways is also discussed.
Identifiants
pubmed: 34199223
pii: v13061139
doi: 10.3390/v13061139
pmc: PMC8231932
pii:
doi:
Substances chimiques
Viral Regulatory and Accessory Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31730095
Organisme : National Natural Science Foundation of China
ID : 31902247
Organisme : National Natural Science Foundation of China
ID : 32072846
Organisme : National Natural Science Foundation of China
ID : U1704231
Organisme : China Postdoctoral Science Foundation
ID : 2019T120670, 2018M640717
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