In Silico Prediction of Transcription Factor Collaborations Underlying Phenotypic Sexual Dimorphism in Zebrafish (
PC-TraFF
colour gene
sex gene
sexual dimorphism
transcription factor
zebrafish
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
07 06 2021
07 06 2021
Historique:
received:
24
03
2021
revised:
02
06
2021
accepted:
05
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
22
9
2021
Statut:
epublish
Résumé
The transcriptional regulation of gene expression in higher organisms is essential for different cellular and biological processes. These processes are controlled by transcription factors and their combinatorial interplay, which are crucial for complex genetic programs and transcriptional machinery. The regulation of sex-biased gene expression plays a major role in phenotypic sexual dimorphism in many species, causing dimorphic gene expression patterns between two different sexes. The role of transcription factor (TF) in gene regulatory mechanisms so far has not been studied for sex determination and sex-associated colour patterning in zebrafish with respect to phenotypic sexual dimorphism. To address this open biological issue, we applied bioinformatics approaches for identifying the predicted TF pairs based on their binding sites for sex and colour genes in zebrafish. In this study, we identified 25 (e.g., STAT6-GATA4; JUN-GATA4; SOX9-JUN) and 14 (e.g., IRF-STAT6; SOX9-JUN; STAT6-GATA4) potentially cooperating TFs based on their binding patterns in promoter regions for sex determination and colour pattern genes in zebrafish, respectively. The comparison between identified TFs for sex and colour genes revealed several predicted TF pairs (e.g., STAT6-GATA4; JUN-SOX9) are common for both phenotypes, which may play a pivotal role in phenotypic sexual dimorphism in zebrafish.
Identifiants
pubmed: 34200177
pii: genes12060873
doi: 10.3390/genes12060873
pmc: PMC8227731
pii:
doi:
Substances chimiques
Transcription Factors
0
Zebrafish Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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