Role of FGF15 in Hepatic Surgery in the Presence of Tumorigenesis: Dr. Jekyll or Mr. Hyde?
fibroblast growth factor
hepatocellular carcinoma
ischemia-reperfusion injury
liver surgery
liver transplantation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
07 06 2021
07 06 2021
Historique:
received:
26
03
2021
revised:
26
05
2021
accepted:
04
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
27
10
2021
Statut:
epublish
Résumé
The pro-tumorigenic activity of fibroblast growth factor (FGF) 19 (FGF15 in its rodent orthologue) in hepatocellular carcinoma (HCC), as well as the unsolved problem that ischemia-reperfusion (IR) injury supposes in liver surgeries, are well known. However, it has been shown that FGF15 administration protects against liver damage and regenerative failure in liver transplantation (LT) from brain-dead donors without tumor signals, providing a benefit in avoiding IR injury. The protection provided by FGF15/19 is due to its anti-apoptotic and pro-regenerative properties, which make this molecule a potentially beneficial or harmful factor, depending on the disease. In the present review, we describe the preclinical models currently available to understand the signaling pathways responsible for the apparent controversial effects of FGF15/19 in the liver (to repair a damaged liver or to promote tumorigenesis). As well, we study the potential pharmacological use that has the activation or inhibition of FGF15/19 pathways depending on the disease to be treated. We also discuss whether FGF15/19 non-pro-tumorigenic variants, which have been developed for the treatment of liver diseases, might be promising approaches in the surgery of hepatic resections and LT using healthy livers and livers from extended-criteria donors.
Identifiants
pubmed: 34200439
pii: cells10061421
doi: 10.3390/cells10061421
pmc: PMC8228386
pii:
doi:
Substances chimiques
FGF19 protein, human
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : RTI2018-095114-B-I00
Organisme : Secretaria d'Universitats i Recerca
ID : 2017SGR-551
Organisme : COST action Programs
ID : CA17103 (DARTER)
Organisme : COMULIS
ID : CA17121
Organisme : PROEURO-DILI-NETWORK
ID : CA17112
Organisme : TUMIEE
ID : CA17126
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