The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells.
Adipose Tissue
/ metabolism
Animals
Breast Neoplasms
/ metabolism
Cell Line, Tumor
Cell Movement
Female
Humans
Large Neutral Amino Acid-Transporter 1
/ metabolism
Leucine
/ metabolism
Mice, Inbred C57BL
Obesity
/ metabolism
Receptors, Estrogen
/ metabolism
Signal Transduction
TOR Serine-Threonine Kinases
/ metabolism
LAT1
breast cancer
leucine
mTOR
obesity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jun 2021
23 Jun 2021
Historique:
received:
27
05
2021
revised:
15
06
2021
accepted:
17
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
4
8
2021
Statut:
epublish
Résumé
Obesity increases the risk of postmenopausal breast cancer (BC). This risk is mediated by obesity-induced changes in the adipose-derived secretome (ADS). The pathogenesis of BC in obesity is stimulated by mTOR hyperactivity. In obesity, leucine might support mTOR hyperactivity. Leucine uptake by BC cells is through L-Type Amino Acid Transporter 1 (LAT1). Our objective was to link obesity-ADS induction of LAT1 to the induction of mTOR signaling. Lean- and obese-ADS were obtained from lean and obese mice, respectively. Breast ADS was obtained from BC patients. Estrogen-receptor-positive BC cells were stimulated with ADS. LAT1 activity was determined by uptake of
Identifiants
pubmed: 34201429
pii: ijms22136706
doi: 10.3390/ijms22136706
pmc: PMC8268498
pii:
doi:
Substances chimiques
Large Neutral Amino Acid-Transporter 1
0
Receptors, Estrogen
0
SLC7A5 protein, human
0
MTOR protein, human
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Leucine
GMW67QNF9C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : DK-67420; DK-108054; P20GM121299-01A1
Pays : United States
Organisme : Veteran's Administration Merit
ID : BX003443-01
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