Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring.
O-GlcNAcylation
O-linked N-acetylglucosamine (GlcNAc) transferase
OGT
beta-cells
fetal programming
glucose homeostasis
islet
metabolism
pancreas
placenta
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Jun 2021
28 Jun 2021
Historique:
received:
25
05
2021
revised:
19
06
2021
accepted:
20
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
10
8
2021
Statut:
epublish
Résumé
Placental dysfunction can lead to fetal growth restriction which is associated with perinatal morbidity and mortality. Fetal growth restriction increases the risk of obesity and diabetes later in life. Placental O-GlcNAc transferase (OGT) has been identified as a marker and a mediator of placental insufficiency in the setting of prenatal stress, however, its role in the fetal programming of metabolism and glucose homeostasis remains unknown. We aim to determine the long-term metabolic outcomes of offspring with a reduction in placental OGT. Mice with a partial reduction and a full knockout of placenta-specific OGT were generated utilizing the Cre-Lox system. Glucose homeostasis and metabolic parameters were assessed on a normal chow and a high-fat diet in both male and female adult offspring. A reduction in placental OGT did not demonstrate differences in the metabolic parameters or glucose homeostasis compared to the controls on a standard chow. The high-fat diet provided a metabolic challenge that revealed a decrease in body weight gain (
Identifiants
pubmed: 34203166
pii: ijms22136918
doi: 10.3390/ijms22136918
pmc: PMC8267851
pii:
doi:
Substances chimiques
Insulin
0
N-Acetylglucosaminyltransferases
EC 2.4.1.-
Acetylglucosamine
V956696549
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01DK115720
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32DK108733
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R21HD100840
Organisme : NIDDK NIH HHS
ID : R21DK112144
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007203
Pays : United States
Organisme : Regenerative Medicine Minnesota
ID : 00085565
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