Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
06 Jun 2021
Historique:
received: 26 04 2021
revised: 24 05 2021
accepted: 03 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 15 7 2021
Statut: epublish

Résumé

This work aimed to construct 3D-QSAR CoMFA and CoMSIA models for a series of 31 FAAH inhibitors, containing the 1,3,4-oxadiazol-2-one moiety. The obtained models were characterized by good statistical parameters: CoMFA Q

Identifiants

pubmed: 34204026
pii: ijms22116108
doi: 10.3390/ijms22116108
pmc: PMC8201265
pii:
doi:

Substances chimiques

1,3,4-oxadiazol-2(3H)-one 0
Oxadiazoles 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Uniwersytet Medyczny w Lublinie
ID : DS33

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Auteurs

Agata Zięba (A)

Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, PL-20059 Lublin, Poland.

Tuomo Laitinen (T)

School of Pharmacy, University of Eastern Finland, FI-70211 Kuopio, Finland.

Jayendra Z Patel (JZ)

Division of Pharmaceutical Chemistry and Technology, University of Helsinki, FI-00790 Helsinki, Finland.

Antti Poso (A)

School of Pharmacy, University of Eastern Finland, FI-70211 Kuopio, Finland.
Department of Internal Medicine VIII, University Hospital Tübingen, DE-72076 Tübingen, Germany.

Agnieszka A Kaczor (AA)

Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, PL-20059 Lublin, Poland.
School of Pharmacy, University of Eastern Finland, FI-70211 Kuopio, Finland.

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Classifications MeSH