FcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review.
Fc-fusion protein
biologics
immunoglobulin G
monoclonal antibody
nasal route
neonatal Fc receptor
transcytosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Jun 2021
17 Jun 2021
Historique:
received:
10
05
2021
revised:
07
06
2021
accepted:
11
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
20
7
2021
Statut:
epublish
Résumé
FcRn plays a major role in regulating immune homeostasis, but it is also able to transport biologics across cellular barriers. The question of whether FcRn could be an efficient transporter of biologics across the nasal epithelial barrier is of particular interest, as it would allow a less invasive strategy for the administration of biologics in comparison to subcutaneous, intramuscular or intravenous administrations, which are often used in clinical practice. A focused systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. It was registered on the international prospective register of systematic reviews PROSPERO, which helped in identifying articles that met the inclusion criteria. Clinical and preclinical studies involving FcRn and the nasal delivery of biologics were screened, and the risk of bias was assessed across studies using the Oral Health Assessment Tool (OHAT). Among the 12 studies finally included in this systematic review (out of the 758 studies screened), 11 demonstrated efficient transcytosis of biologics through the nasal epithelium. Only three studies evaluated the potential toxicity of biologics' intranasal delivery, and they all showed that it was safe. This systematic review confirmed that FcRn is expressed in the nasal airway and the olfactory epithelium, and that FcRn may play a role in IgG and/or IgG-derived molecule-transcytosis across the airway epithelium. However, additional research is needed to better characterize the pharmacokinetic and pharmacodynamic properties of biologics after their intranasal delivery.
Identifiants
pubmed: 34204226
pii: ijms22126475
doi: 10.3390/ijms22126475
pmc: PMC8234196
pii:
doi:
Substances chimiques
Biological Products
0
Biomarkers
0
Histocompatibility Antigens Class I
0
Receptors, Fc
0
Fc receptor, neonatal
TW3XAW0RCY
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
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