Distinct Gene Expression Profiles in Colonic Organoids from Normotensive and the Spontaneously Hypertensive Rats.
antigen presentation
butyrate
colonic organoid
hypertension
immune response
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
17 06 2021
17 06 2021
Historique:
received:
29
04
2021
revised:
11
06
2021
accepted:
15
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Hypertension is associated with gut bacterial dysbiosis and gut pathology in animal models and people. Butyrate-producing gut bacteria are decreased in hypertension. RNA-seq analysis of gut colonic organoids prepared from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats was used to test the hypothesis that impaired interactions between the gut microbiome and gut epithelium are involved and that these would be remediated with butyrate supplementation. Gene expressions in immune responses including antigen presentation and antiviral pathways were decreased in the gut epithelium of the SHR in organoids and confirmed in vivo; these deficits were corrected by butyrate supplementation. Deficits in gene expression driving epithelial proliferation and differentiation were also observed in SHR. These findings highlight the importance of aligned interactions of the gut microbiome and gut immune responses to blood pressure homeostasis.
Identifiants
pubmed: 34204247
pii: cells10061523
doi: 10.3390/cells10061523
pmc: PMC8234507
pii:
doi:
Substances chimiques
Butyrates
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Institutes of Health National Heart, Lung, and Blood Institute grants
ID : HL033610
Organisme : National Institutes of Health National Heart, Lung, and Blood Institute grants
ID : HL110170
Organisme : National Institutes of Health National Heart, Lung, and Blood Institute grants
ID : HL132448
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