Targeting Mitochondria in Diabetes.
blood cells
diabetes therapy
exercise
insulin resistance
liver
mitochondria
respiration
respiratory capacity
skeletal muscle
type 2 diabetes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jun 2021
21 Jun 2021
Historique:
received:
01
06
2021
revised:
14
06
2021
accepted:
15
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
8
2021
Statut:
epublish
Résumé
Type 2 diabetes (T2D), one of the most prevalent noncommunicable diseases, is often preceded by insulin resistance (IR), which underlies the inability of tissues to respond to insulin and leads to disturbed metabolic homeostasis. Mitochondria, as a central player in the cellular energy metabolism, are involved in the mechanisms of IR and T2D. Mitochondrial function is affected by insulin resistance in different tissues, among which skeletal muscle and liver have the highest impact on whole-body glucose homeostasis. This review focuses on human studies that assess mitochondrial function in liver, muscle and blood cells in the context of T2D. Furthermore, different interventions targeting mitochondria in IR and T2D are listed, with a selection of studies using respirometry as a measure of mitochondrial function, for better data comparison. Altogether, mitochondrial respiratory capacity appears to be a metabolic indicator since it decreases as the disease progresses but increases after lifestyle (exercise) and pharmacological interventions, together with the improvement in metabolic health. Finally, novel therapeutics developed to target mitochondria have potential for a more integrative therapeutic approach, treating both causative and secondary defects of diabetes.
Identifiants
pubmed: 34205752
pii: ijms22126642
doi: 10.3390/ijms22126642
pmc: PMC8233932
pii:
doi:
Substances chimiques
Hypoglycemic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 451-03-68/2020-14/200110
Références
J Endocrinol. 2017 Apr;233(1):R15-R42
pubmed: 28232636
Int J Mol Sci. 2020 Sep 08;21(18):
pubmed: 32911736
Curr Opin Clin Nutr Metab Care. 2010 Sep;13(5):511-7
pubmed: 20616711
Eur J Endocrinol. 2017 Feb;176(2):R67-R78
pubmed: 27913612
Cells. 2019 Mar 15;8(3):
pubmed: 30875966
Vasc Med. 2014 Feb;19(1):67-74
pubmed: 24558030
Diabetologia. 2014 Mar;57(3):572-81
pubmed: 24310562
Diabetes. 2015 Jun;64(6):2254-64
pubmed: 25552598
Redox Biol. 2017 Apr;11:637-645
pubmed: 28131082
Diabetologia. 2016 Jun;59(6):1098-103
pubmed: 27048250
Cell Metab. 2015 May 5;21(5):739-46
pubmed: 25955209
J Biol Chem. 2009 May 29;284(22):14809-18
pubmed: 19332540
Nat Commun. 2019 Apr 5;10(1):1582
pubmed: 30952843
Nature. 2003 Sep 11;425(6954):191-6
pubmed: 12939617
J Physiol. 2003 Feb 1;546(Pt 3):851-8
pubmed: 12563009
J Clin Endocrinol Metab. 2007 Sep;92(9):3490-7
pubmed: 17595248
Int J Mol Sci. 2019 Oct 24;20(21):
pubmed: 31652915
Diabetes. 2002 Oct;51(10):2944-50
pubmed: 12351431
Diabetologia. 2020 Jun;63(6):1211-1222
pubmed: 32185462
Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E268-E285
pubmed: 30601700
J Hepatol. 2021 May;74(5):1028-1037
pubmed: 33259845
Diabetes. 2007 Jun;56(6):1592-9
pubmed: 17351150
Cell Rep. 2019 Nov 5;29(6):1511-1523.e5
pubmed: 31693892
Diabetes. 2014 Oct;63(10):3279-94
pubmed: 24947355
Sci Rep. 2016 Oct 12;6:35170
pubmed: 27731374
Acta Physiol (Oxf). 2021 Apr;231(4):e13625
pubmed: 33570804
J Biol Chem. 2019 Feb 22;294(8):2839-2853
pubmed: 30591586
Gastroenterology. 2001 Apr;120(5):1183-92
pubmed: 11266382
Diabetes Care. 2014 Jul;37(7):1924-30
pubmed: 24722500
Biochim Biophys Acta. 2014 Feb;1837(2):270-6
pubmed: 24212054
JHEP Rep. 2019 Jul 19;1(4):312-328
pubmed: 32039382
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71
pubmed: 12832613
Diabetes. 2008 Nov;57(11):2943-9
pubmed: 18678616
Diabetes Obes Metab. 2010 Sep;12(9):806-14
pubmed: 20649633
Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E503-E512
pubmed: 31211617
BMC Sports Sci Med Rehabil. 2018 Nov 23;10:21
pubmed: 30479775
J Appl Physiol (1985). 1997 Jul;83(1):166-71
pubmed: 9216960
Endocr Connect. 2015 Mar;4(1):R1-R15
pubmed: 25385852
Biochem J. 2016 Aug 1;473(15):2295-314
pubmed: 27470593
Int J Biochem Cell Biol. 2014 May;50:67-72
pubmed: 24569118
Nat Med. 2004 May;10(5):530-4
pubmed: 15107844
J Physiol. 2021 Feb 10;:
pubmed: 33569797
Metabolism. 2017 Apr;69:24-32
pubmed: 28285649
Diabetes Res Clin Pract. 2019 Nov;157:107843
pubmed: 31518657
Endocrinol Diabetes Metab Case Rep. 2018 Sep 25;2018:
pubmed: 30306776
J Sport Health Sci. 2020 Sep;9(5):386-393
pubmed: 32780692
Physiol Rep. 2020 Jun;8(12):e14489
pubmed: 32562386
Nat Med. 2009 Nov;15(11):1307-11
pubmed: 19838201
Diabetologia. 2020 Aug;63(8):1464-1474
pubmed: 32529412
Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E694-702
pubmed: 16263768
Nature. 2001 Sep 13;413(6852):131-8
pubmed: 11557972
Am J Clin Nutr. 2016 Jul;104(1):215-27
pubmed: 27194304
Cell Death Discov. 2016 Jan 18;2:15072
pubmed: 27551496
Alcohol Clin Exp Res. 2007 Jan;31(1 Suppl):S54-60
pubmed: 17331167
Clin Sci (Lond). 2018 Dec 5;132(23):2509-2518
pubmed: 30401689
Biochim Biophys Acta. 2014 Apr;1840(4):1404-12
pubmed: 24246956
Diabetes. 2010 Mar;59(3):572-9
pubmed: 20028948
Diabetologia. 2011 Jun;54(6):1427-36
pubmed: 21424396
Diabetes Obes Metab. 2009 Apr;11(4):355-60
pubmed: 19267714
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7996-8001
pubmed: 12808136
JAMA. 1999 Nov 3;282(17):1659-64
pubmed: 10553793
Metabolism. 2021 Jan;114:154416
pubmed: 33137378
Nature. 2014 Jun 26;510(7506):542-6
pubmed: 24847880
Exp Clin Endocrinol Diabetes. 2012 Apr;120(4):248-51
pubmed: 21922457
Endocr Rev. 2010 Jun;31(3):364-95
pubmed: 20156986
Exp Gerontol. 2015 Oct;70:84-91
pubmed: 26226578
Radiology. 2010 Aug;256(2):466-73
pubmed: 20656836
Endocrinol Diabetes Metab. 2021 Feb 23;4(2):e00211
pubmed: 33855213
Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E43-51
pubmed: 21917634
Nat Genet. 2003 Jul;34(3):267-73
pubmed: 12808457
PLoS One. 2011;6(10):e26883
pubmed: 22046392
J Biol Chem. 1967 May 10;242(9):2278-82
pubmed: 4290225
Expert Opin Pharmacother. 2020 Jun;21(8):871-882
pubmed: 32108532
Front Endocrinol (Lausanne). 2020 Nov 23;11:592129
pubmed: 33329397
Life Sci. 2020 Apr 15;247:117414
pubmed: 32035928
Am J Gastroenterol. 2003 Oct;98(10):2335-6
pubmed: 14572600
Clin Rehabil. 2008 Jun;22(6):483-92
pubmed: 18511528
J Mol Med (Berl). 2015 Aug;93(8):831-43
pubmed: 26108617
Diabetes. 2015 Apr;64(4):1193-201
pubmed: 25352640
Nat Rev Endocrinol. 2011 Sep 13;8(2):92-103
pubmed: 21912398
Science. 2005 Jan 21;307(5708):384-7
pubmed: 15662004
Cell. 2015 Oct 22;163(3):560-9
pubmed: 26496603
Diabetes. 2009 Apr;58(4):773-95
pubmed: 19336687
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5422-7
pubmed: 23513224
J Am Coll Cardiol. 2013 Jan 8;61(1):44-53
pubmed: 23287371
Diabetologia. 2007 Apr;50(4):790-6
pubmed: 17334651
Diabetes Care. 2011 Feb;34(2):448-53
pubmed: 21216854
Diabetes Care. 2016 Dec;39(12):2211-2217
pubmed: 27852684
Diabetes. 2016 Sep;65(9):2784-94
pubmed: 27381369
Physiol Rep. 2018 Jun;6(12):e13741
pubmed: 29932506
EBioMedicine. 2021 Mar;65:103244
pubmed: 33647769
Biochim Biophys Acta. 2016 Oct;1863(10):2436-42
pubmed: 26826034
J Appl Physiol Respir Environ Exerc Physiol. 1984 Apr;56(4):831-8
pubmed: 6373687
Free Radic Biol Med. 2019 Sep;141:483-491
pubmed: 31349039
Cardiovasc Drugs Ther. 2021 Jun;35(3):491-503
pubmed: 32770520
Sci Rep. 2015 May 06;5:9884
pubmed: 25943561
Drugs R D. 2015 Sep;15(3):227-32
pubmed: 26254210
Diabetes. 1988 Jun;37(6):667-87
pubmed: 3289989
Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E818-25
pubmed: 15585590
Eur J Clin Invest. 2015 Jul;45(7):745-54
pubmed: 25991405
Biochem J. 2000 Jun 15;348 Pt 3:607-14
pubmed: 10839993
Hepatology. 2009 Oct;50(4):1079-86
pubmed: 19637187
Nat Med. 2018 Sep;24(9):1384-1394
pubmed: 30038219
PLoS Med. 2005 Sep;2(9):e233
pubmed: 16089501
Transl Res. 2010 Jul;156(1):15-25
pubmed: 20621033
J Physiol. 2016 Sep 15;594(18):5105-23
pubmed: 26503074
J Appl Physiol (1985). 2018 Jun 1;124(6):1605-1615
pubmed: 29543139
Exerc Sport Sci Rev. 2019 Jul;47(3):151-156
pubmed: 30985475
J Hepatol. 1999 Sep;31(3):430-4
pubmed: 10488700
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H761-7
pubmed: 18567705
Diabetes Care. 2013 Mar;36(3):565-8
pubmed: 23160726
Front Endocrinol (Lausanne). 2017 Dec 15;8:347
pubmed: 29326655
Free Radic Biol Med. 2016 Sep;98:123-130
pubmed: 26654757
Diabetes. 2018 Jul;67(7):1369-1379
pubmed: 29643061
Diabetologia. 2012 Feb;55(2):443-9
pubmed: 22009334
Eur J Appl Physiol. 2016 Aug;116(8):1445-54
pubmed: 27251406
J Biol Chem. 2000 Jan 7;275(1):223-8
pubmed: 10617608
BMJ Open Sport Exerc Med. 2017 Mar 1;2(1):e000143
pubmed: 28879026