Polyamines: Functions, Metabolism, and Role in Human Disease Management.
biosynthesis
disease prevention
human health
nutritional role
polyamines
Journal
Medical sciences (Basel, Switzerland)
ISSN: 2076-3271
Titre abrégé: Med Sci (Basel)
Pays: Switzerland
ID NLM: 101629322
Informations de publication
Date de publication:
09 06 2021
09 06 2021
Historique:
received:
03
05
2021
revised:
05
06
2021
accepted:
07
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses. PAs are the integrated part of the cellular and genetic metabolism and help in transcription, translation, signaling, and post-translational modifications. At the cellular level, PA concentration may influence the condition of various diseases in the body. For instance, a high PA level is detrimental to patients suffering from aging, cognitive impairment, and cancer. The levels of PAs decline with age in humans, which is associated with different health disorders. On the other hand, PAs reduce the risk of many cardiovascular diseases and increase longevity, when taken in an optimum quantity. Therefore, a controlled diet is an easy way to maintain the level of PAs in the body. Based on the nutritional intake of PAs, healthy cell functioning can be maintained. Moreover, several diseases can also be controlled to a higher extend via maintaining the metabolism of PAs. The present review discusses the types, important functions, and metabolism of PAs in humans. It also highlights the nutritional role of PAs in the prevention of various diseases.
Identifiants
pubmed: 34207607
pii: medsci9020044
doi: 10.3390/medsci9020044
pmc: PMC8293435
pii:
doi:
Substances chimiques
Polyamines
0
Spermine
2FZ7Y3VOQX
Spermidine
U87FK77H25
Putrescine
V10TVZ52E4
Types de publication
Journal Article
Review
Langues
eng
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