Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins.
Antineoplastic Agents
/ pharmacology
Cell Death
Cell Line, Tumor
Cell Movement
Cell Proliferation
Computational Biology
/ methods
Epigenesis, Genetic
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/ pharmacology
Mevalonic Acid
/ metabolism
Pancreatic Neoplasms
/ drug therapy
Transcriptome
/ drug effects
DNA microarray
HMG-CoA reductase inhibitors
atorvastatin
cerivastatin
fluvastatin
pancreatic cancer
pitavastatin
pravastatin
simvastatin
statins
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Jun 2021
09 Jun 2021
Historique:
received:
16
03
2021
revised:
21
05
2021
accepted:
26
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
30
7
2021
Statut:
epublish
Résumé
Statins have been widely used for the treatment of hypercholesterolemia due to their ability to inhibit HMG-CoA reductase, the rate-limiting enzyme of de novo cholesterol synthesis, via the so-called mevalonate pathway. However, their inhibitory action also causes depletion of downstream intermediates of the pathway, resulting in the pleiotropic effects of statins, including the beneficial impact in the treatment of cancer. In our study, we compared the effect of all eight existing statins on the expression of genes, the products of which are implicated in cancer inhibition and suggested the molecular mechanisms of their action in epigenetic and posttranslational regulation, and in cell-cycle arrest, death, migration, or invasion of the cancer cells.
Identifiants
pubmed: 34207840
pii: molecules26123528
doi: 10.3390/molecules26123528
pmc: PMC8226792
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Mevalonic Acid
S5UOB36OCZ
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Operational Programme Research, Development and Education
ID : No. CZ.02.1.01/0.0/0.0/16_019/0000785
Organisme : the Slovak Research and Development Agency
ID : APVV-15-0217
Organisme : the Czech Ministry of Health
ID : RVO-VFN64165/2021
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