Aberrant Expression of Long Non Coding RNA HOTAIR and De-Regulation of the Paralogous 13 HOX Genes Are Strongly Associated with Aggressive Behavior of Gastro-Entero-Pancreatic Neuroendocrine Tumors.
Adult
Aged
Aged, 80 and over
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Genes, Homeobox
Humans
Intestinal Neoplasms
/ genetics
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Neuroendocrine Tumors
/ genetics
Pancreatic Neoplasms
/ genetics
RNA, Long Noncoding
/ genetics
Stomach Neoplasms
/ genetics
Up-Regulation
GEP-NENs
HOX genes
lncRNA HOTAIR
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
04
06
2021
revised:
18
06
2021
accepted:
25
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
30
7
2021
Statut:
epublish
Résumé
Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) are rare diseases occurring in the gastrointestinal tract and pancreas. They are characterized by the loss of epithelial tubular gland elements, and by the increased expression of neuroendocrine markers. GEP-NENs are subdivided into two histo-pathological types, gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) and gastro-entero-pancreatic neuroendocrine carcinomas (GEP-NECs). According to WHO 2017 and 2019 classification criteria are graded and staged in four categories, NET-G1, NET-G2, NET-G3, and NEC-G3. The molecular characterization of these tumors can be fundamental for the identification of new diagnostic, prognostic and predictive biomarkers. The main purpose of this study was to analyze the expression of the paralogous 13 HOX genes, normally involved in embryogenic development and frequently deregulated in human cancers, and of the HOX regulating lncRNA
Identifiants
pubmed: 34208964
pii: ijms22137049
doi: 10.3390/ijms22137049
pmc: PMC8268982
pii:
doi:
Substances chimiques
HOTAIR long untranslated RNA, human
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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