Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
30 Jun 2021
Historique:
received: 05 06 2021
revised: 25 06 2021
accepted: 25 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 22 7 2021
Statut: epublish

Résumé

Neuroinflammation is a pathological hallmark of several neurodegenerative disorders and plays a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS). It has been implicated as driver of disease progression and is observed in ALS patients, as well as in the transgenic SOD1

Identifiants

pubmed: 34209129
pii: ijms22137066
doi: 10.3390/ijms22137066
pmc: PMC8269060
pii:
doi:

Substances chimiques

Peptides 0
SOD1 G93A protein EC 1.15.1.1
Superoxide Dismutase EC 1.15.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Russian Science Foundation
ID : 20-64-46027
Organisme : Forschungszentrum Jülich
ID : Technology Transfer Fund
Organisme : Impuls und Vernetzungs-Fonds der Helmholtzgemeinschaft
ID : Portfolio Drug Research

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Auteurs

Julia Post (J)

Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.

Anja Schaffrath (A)

Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.

Ian Gering (I)

Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.

Sonja Hartwig (S)

Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
German Center for Diabetes Research, Partner Düsseldorf, 85764 München-Neuherberg, Germany.

Stefan Lehr (S)

Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
German Center for Diabetes Research, Partner Düsseldorf, 85764 München-Neuherberg, Germany.

N Jon Shah (NJ)

Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, Germany.
Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, 52425 Jülich, Germany.
JARA-Brain-Translational Medicine, 52062 Aachen, Germany.
Department of Neurology, RWTH Aachen University, 52062 Aachen, Germany.

Karl-Josef Langen (KJ)

Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, Germany.
Department of Nuclear Medicine, RWTH Aachen University, 52062 Aachen, Germany.

Dieter Willbold (D)

Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.
Institut für Physikalische Biologie, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany.

Janine Kutzsche (J)

Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, Germany.

Antje Willuweit (A)

Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, Germany.

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