Janine Kutzsche

Affiliations

Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52425 Jülich, Germany.
JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.

Publications (20)

All

Journal of medicinal chemistry

Avec: Eduard V Bocharov , Lothar Gremer , Anatoly S Urban , Ivan S Okhrimenko , Pavel E Volynsky , Kirill D Nadezhdin , Olga V Bocharova , Daniil A Kornilov , Yuliya A Zagryadskaya , Anna V Kamynina , Pavel K Kuzmichev , Janine Kutzsche , Najoua Bolakhrif , Andreas Müller-Schiffmann , Norbert A Dencher , Alexander S Arseniev , Roman G Efremov , Valentin I Gordeliy , Dieter Willbold

Do We Need Anti-Prion Compounds to Treat Alzheimer's Disease?

Molecules (Basel, Switzerland)

Avec: Dieter Willbold , Janine Kutzsche

Elevated Aβ aggregates in feces from Alzheimer's disease patients: a proof-of-concept study.

Alzheimer's research & therapy

Avec: Marlene Pils , Alexandra Dybala , Anja Schaffrath , Fabian Rehn , Janine Kutzsche , Lara Blömeke , Markus Tusche , Pelin Özdüzenciler , Tuyen Bujnicki , Victoria Kraemer-Schulien , Hannes Gramespacher , Maximilian H T Schmieschek , Michael T Barbe , Oezguer A Onur , Gereon R Fink , Gültekin Tamgüney , Oliver Bannach , Dieter Willbold

Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2.

Neurobiology of disease

Avec: Sarah Schemmert , Elena Schartmann , Dominik Honold , Christian Zafiu , Tamar Ziehm , Karl-Josef Langen , Nadim Joni Shah , Janine Kutzsche , Antje Willuweit , Dieter Willbold

Oral absorption enhancement of the amyloid-β oligomer eliminating compound RD2 by conjugation with folic acid.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Anne Elfgen , Beatrix Santiago-Schübel , Michelle Hupert , Sarah Schemmert , Elena Schartmann , Markus Tusche , Ian Gering , Christian Zafiu , Janine Kutzsche

Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo.

Cell reports. Medicine

Avec: Bettina Kass , Sarah Schemmert , Christian Zafiu , Marlene Pils , Oliver Bannach , Janine Kutzsche , Tuyen Bujnicki , Dieter Willbold

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers.

Scientific reports

Avec: Anne Elfgen , Michelle Hupert , Kevin Bochinsky , Markus Tusche , Estibaliz González de San Román Martin , Ian Gering , Silvia Sacchi , Loredano Pollegioni , Pitter F Huesgen , Rudolf Hartmann , Beatrix Santiago-Schübel , Janine Kutzsche , Dieter Willbold

Safety and pharmacokinetics of the orally available antiprionic compound PRI-002: A single and multiple ascending dose phase I study.

Alzheimer's & dementia (New York, N. Y.)

Avec: Janine Kutzsche , Dagmar Jürgens , Antje Willuweit , Knut Adermann , Carola Fuchs , Stefanie Simons , Manfred Windisch , Michael Hümpel , Wolfgang Rossberg , Michael Wolzt , Dieter Willbold

Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.

Neurochemistry international

Avec: Marc Sevenich , Dominik Honold , Antje Willuweit , Janine Kutzsche , Jeannine Mohrlüder , Dieter Willbold

Toward the Mode of Action of the Clinical Stage All-d-Enantiomeric Peptide RD2 on Aβ42 Aggregation.

ACS chemical neuroscience

Avec: Tao Zhang , Ian Gering , Janine Kutzsche , Luitgard Nagel-Steger , Dieter Willbold

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer's Mice with Full-blown Pathology.

Molecular neurobiology

Avec: Sarah Schemmert , Elena Schartmann , Christian Zafiu , Bettina Kass , Sonja Hartwig , Stefan Lehr , Oliver Bannach , Karl-Josef Langen , Nadim Joni Shah , Janine Kutzsche , Antje Willuweit , Dieter Willbold

In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer's Disease.

International journal of molecular sciences

Avec: Sarah Schemmert , Luana Cristina Camargo , Dominik Honold , Ian Gering , Janine Kutzsche , Antje Willuweit , Dieter Willbold

PEAβ Triggers Cognitive Decline and Amyloid Burden in a Novel Mouse Model of Alzheimer's Disease.

International journal of molecular sciences

Avec: Luana Cristina Camargo , Michael Schöneck , Nivethini Sangarapillai , Dominik Honold , N Jon Shah , Karl-Josef Langen , Dieter Willbold , Janine Kutzsche , Sarah Schemmert , Antje Willuweit

Evaluation of the

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Antje Willuweit , Swen Humpert , Michael Schöneck , Heike Endepols , Nicole Burda , Lothar Gremer , Ian Gering , Janine Kutzsche , N Jon Shah , Karl-Josef Langen , Bernd Neumaier , Dieter Willbold , Alexander Drzezga

Oral Treatment with d-RD2RD2 Impedes Early Disease Mechanisms in SOD1*G93A Transgenic Mice but Does Not Prolong Survival.

Biomedicines

Avec: Katharina Wintz , Julia Post , Karl-Josef Langen , Dieter Willbold , Antje Willuweit , Janine Kutzsche

A Novel Anti-Inflammatory d-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model.

Molecules (Basel, Switzerland)

Avec: Julia Post , Vanessa Kogel , Anja Schaffrath , Philipp Lohmann , N Jon Shah , Karl-Josef Langen , Dieter Willbold , Antje Willuweit , Janine Kutzsche

Sex-Related Motor Deficits in the Tau-P301L Mouse Model.

Biomedicines

Avec: Luana Cristina Camargo , Dominik Honold , Robert Bauer , N Jon Shah , Karl-Josef Langen , Dieter Willbold , Janine Kutzsche , Antje Willuweit , Sarah Schemmert

Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1

International journal of molecular sciences

Avec: Julia Post , Anja Schaffrath , Ian Gering , Sonja Hartwig , Stefan Lehr , N Jon Shah , Karl-Josef Langen , Dieter Willbold , Janine Kutzsche , Antje Willuweit

An orally available N-type calcium channel inhibitor for the treatment of neuropathic pain.

British journal of pharmacology

Avec: Janine Kutzsche , Gustavo A Guzman , Antje Willuweit , Olaf Kletke , Esther Wollert , Ian Gering , Dagmar Jürgens , Jörg Breitkreutz , Holger Stark , Annette G Beck-Sickinge , Nikolaj Klöcker , Patricia Hidalgo , Dieter Willbold

Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs - A model of sporadic Alzheimer's disease.

Heliyon

Avec: Janine Kutzsche , Sarah Schemmert , Tuyen Bujnicki , Christian Zafiu , Steffen Halbgebauer , Victoria Kraemer-Schulien , Marlene Pils , Lara Blömeke , Julia Post , Andreas Kulawik , Dagmar Jürgens , Wolfgang M Rossberg , Michael Hümpel , Oliver Bannach , Markus Otto , Joseph A Araujo , Antje Willuweit , Dieter Willbold

Réseau de co-auteurs

Dieter Willbold 19 collaborations

Antje Willuweit 13 collaborations

Sarah Schemmert 8 collaborations

Karl-Josef Langen 8 collaborations

Ian Gering 7 collaborations

Dominik Honold 5 collaborations

Christian Zafiu 5 collaborations

N Jon Shah 5 collaborations

Oliver Bannach 4 collaborations

Julia Post 4 collaborations

Marlene Pils 3 collaborations

Anja Schaffrath 3 collaborations

Markus Tusche 3 collaborations

Tuyen Bujnicki 3 collaborations

Elena Schartmann 3 collaborations

Dagmar Jürgens 3 collaborations

Luana Cristina Camargo 3 collaborations

Lothar Gremer 2 collaborations

Lara Blömeke 2 collaborations

Victoria Kraemer-Schulien 2 collaborations

Nadim Joni Shah 2 collaborations

Anne Elfgen 2 collaborations

Beatrix Santiago-Schübel 2 collaborations

Michelle Hupert 2 collaborations

Bettina Kass 2 collaborations

Michael Hümpel 2 collaborations

Sonja Hartwig 2 collaborations

Stefan Lehr 2 collaborations

Michael Schöneck 2 collaborations

Eduard V Bocharov 1 collaboration

Anatoly S Urban 1 collaboration

Ivan S Okhrimenko 1 collaboration

Pavel E Volynsky 1 collaboration

Kirill D Nadezhdin 1 collaboration

Olga V Bocharova 1 collaboration

Daniil A Kornilov 1 collaboration

Yuliya A Zagryadskaya 1 collaboration

Anna V Kamynina 1 collaboration

Pavel K Kuzmichev 1 collaboration

Najoua Bolakhrif 1 collaboration

Andreas Müller-Schiffmann 1 collaboration

Norbert A Dencher 1 collaboration

Alexander S Arseniev 1 collaboration

Roman G Efremov 1 collaboration

Valentin I Gordeliy 1 collaboration

Alexandra Dybala 1 collaboration

Fabian Rehn 1 collaboration

Pelin Özdüzenciler 1 collaboration

Hannes Gramespacher 1 collaboration

Maximilian H T Schmieschek 1 collaboration

Michael T Barbe 1 collaboration

Oezguer A Onur 1 collaboration

Gereon R Fink 1 collaboration

Gültekin Tamgüney 1 collaboration

Tamar Ziehm 1 collaboration

Kevin Bochinsky 1 collaboration

Estibaliz González de San Román Martin 1 collaboration

Silvia Sacchi 1 collaboration

Loredano Pollegioni 1 collaboration

Pitter F Huesgen 1 collaboration

Rudolf Hartmann 1 collaboration

Knut Adermann 1 collaboration

Carola Fuchs 1 collaboration

Stefanie Simons 1 collaboration

Manfred Windisch 1 collaboration

Wolfgang Rossberg 1 collaboration

Michael Wolzt 1 collaboration

Marc Sevenich 1 collaboration

Jeannine Mohrlüder 1 collaboration

Tao Zhang 1 collaboration

Luitgard Nagel-Steger 1 collaboration

Nivethini Sangarapillai 1 collaboration

Swen Humpert 1 collaboration

Heike Endepols 1 collaboration

Nicole Burda 1 collaboration

Bernd Neumaier 1 collaboration

Alexander Drzezga 1 collaboration

Katharina Wintz 1 collaboration

Vanessa Kogel 1 collaboration

Philipp Lohmann 1 collaboration

Robert Bauer 1 collaboration

Gustavo A Guzman 1 collaboration

Olaf Kletke 1 collaboration

Esther Wollert 1 collaboration

Jörg Breitkreutz 1 collaboration

Holger Stark 1 collaboration

Annette G Beck-Sickinge 1 collaboration

Nikolaj Klöcker 1 collaboration

Patricia Hidalgo 1 collaboration

Steffen Halbgebauer 1 collaboration

Andreas Kulawik 1 collaboration

Wolfgang M Rossberg 1 collaboration

Markus Otto 1 collaboration

Joseph A Araujo 1 collaboration