Lothar Gremer

Affiliations

From the Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40204 Düsseldorf.
the Institute of Complex Systems: Structural Biochemistry (ICS-6), Forschungszentrum Jülich, 52425 Jülich.

Publications (26)

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication.

The Journal of biological chemistry

Avec: Stefan Klinker , Sabine Stindt , Lothar Gremer , Johannes G Bode , Christoph G W Gertzen , Holger Gohlke , Oliver H Weiergräber , Silke Hoffmann , Dieter Willbold

Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin.

Nature communications

Avec: Ricarda Törner , Tatsiana Kupreichyk , Lothar Gremer , Elisa Colas Debled , Daphna Fenel , Sarah Schemmert , Pierre Gans , Dieter Willbold , Guy Schoehn , Wolfgang Hoyer , Jerome Boisbouvier

Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Debabrata Maity , Yujeong Oh , Lothar Gremer , Wolfgang Hoyer , Mazin Magzoub , Andrew D Hamilton

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils.

Nature structural & molecular biology

Avec: Christine Röder , Tatsiana Kupreichyk , Lothar Gremer , Luisa U Schäfer , Karunakar R Pothula , Raimond B G Ravelli , Dieter Willbold , Wolfgang Hoyer , Gunnar F Schröder

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction.

The Journal of biological chemistry

Avec: Jacqueline Georgy , Yvonne Arlt , Jens M Moll , Meryem Ouzin , Hendrik T Weitz , Lothar Gremer , Dieter Willbold , Joachim Grötzinger , Felix Thives-Kurenbach , Jürgen Scheller , Doreen M Floss

Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Debabrata Maity , Yujeong Oh , Lothar Gremer , Wolfgang Hoyer , Mazin Magzoub , Andrew D Hamilton

Structural Impact of N-Terminal Pyroglutamate in an Amyloid-β(3-42) Fibril Probed by Solid-State NMR Spectroscopy.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Luis Gardon , Nina Becker , Lothar Gremer , Henrike Heise

Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus.

Communications biology

Avec: Nadine S Rösener , Lothar Gremer , Michael M Wördehoff , Tatsiana Kupreichyk , Manuel Etzkorn , Philipp Neudecker , Wolfgang Hoyer

TopModel: Template-Based Protein Structure Prediction at Low Sequence Identity Using Top-Down Consensus and Deep Neural Networks.

Journal of chemical theory and computation

Avec: Daniel Mulnaes , Nicola Porta , Rebecca Clemens , Irina Apanasenko , Jens Reiners , Lothar Gremer , Philipp Neudecker , Sander H J Smits , Holger Gohlke

The interaction of insoluble Amyloid-β with soluble Amyloid-β dimers decreases Amyloid-β plaque numbers.

Neuropathology and applied neurobiology

Avec: Else F van Gerresheim , Arne Herring , Lothar Gremer , Andreas Müller-Schiffmann , Kathy Keyvani , Carsten Korth

The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands.

The Biochemical journal

Avec: Neda S Kazemein Jasemi , Christian Herrmann , Eva Magdalena Estirado , Lothar Gremer , Dieter Willbold , Luc Brunsveld , Radovan Dvorsky , Mohammad R Ahmadian

Met/Val129 polymorphism of the full-length human prion protein dictates distinct pathways of amyloid formation.

The Journal of biological chemistry

Avec: Thomas Pauly , Najoua Bolakhrif , Jesko Kaiser , Luitgard Nagel-Steger , Lothar Gremer , Holger Gohlke , Dieter Willbold

Intrinsic Disorder of the Neuronal SNARE Protein SNAP25a in its Pre-fusion Conformation.

Journal of molecular biology

Avec: Tobias Stief , Lothar Gremer , Sonja Pribicevic , Delane F Espinueva , Katharina Vormann , Ralf Biehl , Reinhard Jahn , Ángel Pérez-Lara , Nils-Alexander Lakomek

Atomic Resolution Insights into pH Shift Induced Deprotonation Events in LS-Shaped Aβ(1-42) Amyloid Fibrils.

Journal of the American Chemical Society

Avec: Nina Becker , Benedikt Frieg , Lothar Gremer , Tatsiana Kupreichyk , Luis Gardon , Patrick Freiburg , Philipp Neudecker , Dieter Willbold , Holger Gohlke , Henrike Heise

Binding modes of thioflavin T and Congo red to the fibril structure of amyloid-β(1-42).

Chemical communications (Cambridge, England)

Avec: Benedikt Frieg , Lothar Gremer , Henrike Heise , Dieter Willbold , Holger Gohlke

Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents.

RSC chemical biology

Avec: Debabrata Maity , Sunil Kumar , Ruyof AlHussein , Lothar Gremer , Madeline Howarth , Laura Karpauskaite , Wolfgang Hoyer , Mazin Magzoub , Andrew D Hamilton

All

Journal of medicinal chemistry

Avec: Eduard V Bocharov , Lothar Gremer , Anatoly S Urban , Ivan S Okhrimenko , Pavel E Volynsky , Kirill D Nadezhdin , Olga V Bocharova , Daniil A Kornilov , Yuliya A Zagryadskaya , Anna V Kamynina , Pavel K Kuzmichev , Janine Kutzsche , Najoua Bolakhrif , Andreas Müller-Schiffmann , Norbert A Dencher , Alexander S Arseniev , Roman G Efremov , Valentin I Gordeliy , Dieter Willbold

Rapid

Chemical communications (Cambridge, England)

Avec: Swen Humpert , Mohamed A Omrane , Elizaveta A Urusova , Lothar Gremer , Dieter Willbold , Heike Endepols , Raisa N Krasikova , Bernd Neumaier , Boris D Zlatopolskiy

DNA-binding and protein structure of nuclear factors likely acting in genetic information processing in the

Proceedings of the National Academy of Sciences of the United States of America

Avec: Luis Macorano , Taniya M Binny , Tobias Spiegl , Victoria Klimenko , Anna Singer , Linda Oberleitner , Violetta Applegate , Sarah Seyffert , Anja Stefanski , Lothar Gremer , Christoph G W Gertzen , Astrid Höppner , Sander H J Smits , Eva C M Nowack

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy.

Nature communications

Avec: Christine Röder , Nicola Vettore , Lena N Mangels , Lothar Gremer , Raimond B G Ravelli , Dieter Willbold , Wolfgang Hoyer , Alexander K Buell , Gunnar F Schröder

Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases.

Arteriosclerosis, thrombosis, and vascular biology

Avec: Irena Krueger , Lothar Gremer , Lena Mangels , Meike Klier , Kerstin Jurk , Dieter Willbold , Hans H Bock , Margitta Elvers

Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy.

The Journal of biological chemistry

Avec: Anna S König , Nadine S Rösener , Lothar Gremer , Markus Tusche , Daniel Flender , Elke Reinartz , Wolfgang Hoyer , Philipp Neudecker , Dieter Willbold , Henrike Heise

CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain.

International journal of molecular sciences

Avec: Niloufar Mosaddeghzadeh , Silke Pudewell , Farhad Bazgir , Neda S Kazemein Jasemi , Oliver H F Krumbach , Lothar Gremer , Dieter Willbold , Radovan Dvorsky , Mohammad R Ahmadian

Evaluation of the

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Antje Willuweit , Swen Humpert , Michael Schöneck , Heike Endepols , Nicole Burda , Lothar Gremer , Ian Gering , Janine Kutzsche , N Jon Shah , Karl-Josef Langen , Bernd Neumaier , Dieter Willbold , Alexander Drzezga

Cryo-EM of Aβ fibrils from mouse models find tg-APP

Nature neuroscience

Avec: Mara Zielinski , Fernanda S Peralta Reyes , Lothar Gremer , Sarah Schemmert , Benedikt Frieg , Luisa U Schäfer , Antje Willuweit , Lili Donner , Margitta Elvers , Lars N G Nilsson , Stina Syvänen , Dag Sehlin , Martin Ingelsson , Dieter Willbold , Gunnar F Schröder

Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome.

Cell reports

Avec: Alexandra Viktoria Busley , Óscar Gutiérrez-Gutiérrez , Elke Hammer , Fabian Koitka , Amin Mirzaiebadizi , Martin Steinegger , Constantin Pape , Linda Böhmer , Henning Schroeder , Mandy Kleinsorge , Melanie Engler , Ion Cristian Cirstea , Lothar Gremer , Dieter Willbold , Janine Altmüller , Felix Marbach , Gerd Hasenfuss , Wolfram-Hubertus Zimmermann , Mohammad Reza Ahmadian , Bernd Wollnik , Lukas Cyganek

Réseau de co-auteurs

Dieter Willbold 17 collaborations

Wolfgang Hoyer 8 collaborations

Holger Gohlke 5 collaborations

Tatsiana Kupreichyk 4 collaborations

Henrike Heise 4 collaborations

Philipp Neudecker 4 collaborations

Debabrata Maity 3 collaborations

Mazin Magzoub 3 collaborations

Andrew D Hamilton 3 collaborations

Gunnar F Schröder 3 collaborations

Benedikt Frieg 3 collaborations

Christoph G W Gertzen 2 collaborations

Sarah Schemmert 2 collaborations

Yujeong Oh 2 collaborations

Christine Röder 2 collaborations

Luisa U Schäfer 2 collaborations

Raimond B G Ravelli 2 collaborations

Luis Gardon 2 collaborations

Nina Becker 2 collaborations

Nadine S Rösener 2 collaborations

Sander H J Smits 2 collaborations

Andreas Müller-Schiffmann 2 collaborations

Neda S Kazemein Jasemi 2 collaborations

Radovan Dvorsky 2 collaborations

Mohammad R Ahmadian 2 collaborations

Najoua Bolakhrif 2 collaborations

Janine Kutzsche 2 collaborations

Swen Humpert 2 collaborations

Heike Endepols 2 collaborations

Bernd Neumaier 2 collaborations

Margitta Elvers 2 collaborations

Antje Willuweit 2 collaborations

Stefan Klinker 1 collaboration

Sabine Stindt 1 collaboration

Johannes G Bode 1 collaboration

Oliver H Weiergräber 1 collaboration

Silke Hoffmann 1 collaboration

Ricarda Törner 1 collaboration

Elisa Colas Debled 1 collaboration

Daphna Fenel 1 collaboration

Pierre Gans 1 collaboration

Guy Schoehn 1 collaboration

Jerome Boisbouvier 1 collaboration

Karunakar R Pothula 1 collaboration

Jacqueline Georgy 1 collaboration

Yvonne Arlt 1 collaboration

Jens M Moll 1 collaboration

Meryem Ouzin 1 collaboration

Hendrik T Weitz 1 collaboration

Joachim Grötzinger 1 collaboration

Felix Thives-Kurenbach 1 collaboration

Jürgen Scheller 1 collaboration

Doreen M Floss 1 collaboration

Michael M Wördehoff 1 collaboration

Manuel Etzkorn 1 collaboration

Daniel Mulnaes 1 collaboration

Nicola Porta 1 collaboration

Rebecca Clemens 1 collaboration

Irina Apanasenko 1 collaboration

Jens Reiners 1 collaboration

Else F van Gerresheim 1 collaboration

Arne Herring 1 collaboration

Kathy Keyvani 1 collaboration

Carsten Korth 1 collaboration

Christian Herrmann 1 collaboration

Eva Magdalena Estirado 1 collaboration

Luc Brunsveld 1 collaboration

Thomas Pauly 1 collaboration

Jesko Kaiser 1 collaboration

Luitgard Nagel-Steger 1 collaboration

Tobias Stief 1 collaboration

Sonja Pribicevic 1 collaboration

Delane F Espinueva 1 collaboration

Katharina Vormann 1 collaboration

Ralf Biehl 1 collaboration

Reinhard Jahn 1 collaboration

Ángel Pérez-Lara 1 collaboration

Nils-Alexander Lakomek 1 collaboration

Patrick Freiburg 1 collaboration

Sunil Kumar 1 collaboration

Ruyof AlHussein 1 collaboration

Madeline Howarth 1 collaboration

Laura Karpauskaite 1 collaboration

Eduard V Bocharov 1 collaboration

Anatoly S Urban 1 collaboration

Ivan S Okhrimenko 1 collaboration

Pavel E Volynsky 1 collaboration

Kirill D Nadezhdin 1 collaboration

Olga V Bocharova 1 collaboration

Daniil A Kornilov 1 collaboration

Yuliya A Zagryadskaya 1 collaboration

Anna V Kamynina 1 collaboration

Pavel K Kuzmichev 1 collaboration

Norbert A Dencher 1 collaboration

Alexander S Arseniev 1 collaboration

Roman G Efremov 1 collaboration

Valentin I Gordeliy 1 collaboration

Mohamed A Omrane 1 collaboration

Elizaveta A Urusova 1 collaboration

Raisa N Krasikova 1 collaboration

Boris D Zlatopolskiy 1 collaboration

Luis Macorano 1 collaboration

Taniya M Binny 1 collaboration

Tobias Spiegl 1 collaboration

Victoria Klimenko 1 collaboration

Anna Singer 1 collaboration

Linda Oberleitner 1 collaboration

Violetta Applegate 1 collaboration

Sarah Seyffert 1 collaboration

Anja Stefanski 1 collaboration

Astrid Höppner 1 collaboration

Eva C M Nowack 1 collaboration

Nicola Vettore 1 collaboration

Lena N Mangels 1 collaboration

Alexander K Buell 1 collaboration

Irena Krueger 1 collaboration

Lena Mangels 1 collaboration

Meike Klier 1 collaboration

Kerstin Jurk 1 collaboration

Hans H Bock 1 collaboration

Anna S König 1 collaboration

Markus Tusche 1 collaboration

Daniel Flender 1 collaboration

Elke Reinartz 1 collaboration

Niloufar Mosaddeghzadeh 1 collaboration

Silke Pudewell 1 collaboration

Farhad Bazgir 1 collaboration

Oliver H F Krumbach 1 collaboration

Michael Schöneck 1 collaboration

Nicole Burda 1 collaboration

Ian Gering 1 collaboration

N Jon Shah 1 collaboration

Karl-Josef Langen 1 collaboration

Alexander Drzezga 1 collaboration

Mara Zielinski 1 collaboration

Fernanda S Peralta Reyes 1 collaboration

Lili Donner 1 collaboration

Lars N G Nilsson 1 collaboration

Stina Syvänen 1 collaboration

Dag Sehlin 1 collaboration

Martin Ingelsson 1 collaboration

Alexandra Viktoria Busley 1 collaboration

Óscar Gutiérrez-Gutiérrez 1 collaboration

Elke Hammer 1 collaboration

Fabian Koitka 1 collaboration

Amin Mirzaiebadizi 1 collaboration

Martin Steinegger 1 collaboration

Constantin Pape 1 collaboration

Linda Böhmer 1 collaboration

Henning Schroeder 1 collaboration

Mandy Kleinsorge 1 collaboration

Melanie Engler 1 collaboration

Ion Cristian Cirstea 1 collaboration

Janine Altmüller 1 collaboration

Felix Marbach 1 collaboration

Gerd Hasenfuss 1 collaboration

Wolfram-Hubertus Zimmermann 1 collaboration

Mohammad Reza Ahmadian 1 collaboration

Bernd Wollnik 1 collaboration

Lukas Cyganek 1 collaboration