Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.
3' Untranslated Regions
Animals
Embryo, Mammalian
/ metabolism
Gene Expression Regulation, Developmental
Intercellular Signaling Peptides and Proteins
/ genetics
Mice
Mice, Knockout
RNA Stability
/ physiology
RNA, Messenger
/ metabolism
RNA-Binding Proteins
/ genetics
Receptors, CCR4
/ genetics
TRPP Cation Channels
/ metabolism
Transcription Factors
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
received:
14
01
2020
accepted:
09
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
23
7
2021
Statut:
epublish
Résumé
Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown cells and the consequent degradation of Dand5 mRNA on the left side. We here examined how the fluid flow induces Dand5 mRNA decay. We found that the first 200 nucleotides in the 3' untranslated region (3'-UTR) of Dand5 mRNA are necessary and sufficient for the left-sided decay and to mediate the response of a 3'-UTR reporter transgene to Ca
Identifiants
pubmed: 34210974
doi: 10.1038/s41467-021-24295-2
pii: 10.1038/s41467-021-24295-2
pmc: PMC8249388
doi:
Substances chimiques
3' Untranslated Regions
0
Bicc1 protein, mouse
0
CNOT3 protein, mouse
0
Ccr4 protein, mouse
0
Dte protein, mouse
0
Intercellular Signaling Peptides and Proteins
0
RNA, Messenger
0
RNA-Binding Proteins
0
Receptors, CCR4
0
TRPP Cation Channels
0
Transcription Factors
0
polycystic kidney disease 2 protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4071Références
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