Beclin-1-Dependent Autophagy Improves Outcomes of Pneumonia-Induced Sepsis.
autophagy
infection
inflammation
pneumonia
sepsis
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
05
2021
accepted:
26
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
We previously demonstrated that promoting Beclin-1-dependent autophagy is cardiac protective during endotoxemia shock, suggesting that autophagy-based approaches may become a promising therapeutic strategy for sepsis. In this study, we applied both genetic and pharmacological approaches to evaluate whether Beclin-1 activation improves sepsis outcomes in a model of pneumonia-induced sepsis. Sepsis was induced in mice by Pulmonary infection by Data suggest that targeted activation of Beclin-1 alleviates adverse outcomes of pneumonia-induced sepsis, and thus, possess a therapeutic potential.
Identifiants
pubmed: 34211859
doi: 10.3389/fcimb.2021.706637
pmc: PMC8239405
doi:
Substances chimiques
Beclin-1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
706637Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM111295
Pays : United States
Informations de copyright
Copyright © 2021 Nikouee, Kim, Ding, Sun and Zang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
FASEB Bioadv. 2021 Jan 25;3(3):123-135
pubmed: 33733054
Antioxid Redox Signal. 2014 Jan 20;20(3):432-42
pubmed: 23971531
PLoS One. 2015 Oct 08;10(10):e0139416
pubmed: 26448624
Front Immunol. 2020 Jul 07;11:1337
pubmed: 32733448
J Infect Dis. 2011 Dec 15;204(12):1971-9
pubmed: 22021621
J Craniofac Surg. 2009 Sep;20(5):1627-8
pubmed: 19816317
Nat Cell Biol. 2010 Sep;12(9):823-30
pubmed: 20811354
Circulation. 2018 Nov 13;138(20):2247-2262
pubmed: 29853517
J Clin Invest. 2007 Jul;117(7):1782-93
pubmed: 17607355
Crit Care Med. 2010 Feb;38(2):367-74
pubmed: 20035219
Crit Care Med. 2006 Oct;34(10):2576-82
pubmed: 16915108
Nature. 1999 Dec 9;402(6762):672-6
pubmed: 10604474
Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L651-63
pubmed: 22245997
Shock. 2011 May;35(5):506-11
pubmed: 21263383
Am J Physiol Lung Cell Mol Physiol. 2014 Sep 1;307(5):L355-63
pubmed: 24993132
Nature. 2018 Jun;558(7708):136-140
pubmed: 29849149
JAMA. 2010 Oct 27;304(16):1787-94
pubmed: 20978258
Surg Infect (Larchmt). 2007 Feb;8(1):41-54
pubmed: 17381396
Cell. 2012 Apr 13;149(2):274-93
pubmed: 22500797
Cancer Cell. 2016 Jul 11;30(1):147-160
pubmed: 27411589
J Virol. 1998 Nov;72(11):8586-96
pubmed: 9765397
PLoS One. 2012;7(8):e43424
pubmed: 22952679
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
J Clin Invest. 2003 Dec;112(12):1809-20
pubmed: 14638851
J Immunol. 2017 Feb 15;198(4):1660-1672
pubmed: 28053235
Nat Immunol. 2011 Mar;12(3):222-30
pubmed: 21151103
Crit Care. 2013 Jul 24;17(4):R160
pubmed: 23883625
Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1847-59
pubmed: 22408027
Circulation. 2016 Mar 29;133(13):1249-63
pubmed: 26915633
Nature. 2013 Feb 14;494(7436):201-6
pubmed: 23364696
Cells. 2019 Feb 10;8(2):
pubmed: 30744190
J Am Soc Nephrol. 2014 Feb;25(2):305-15
pubmed: 24179166
Virulence. 2014 Jan 1;5(1):4-11
pubmed: 24335434