The future of antibiotics begins with discovering new combinations.
antibacterials
antibiotic resistance
antibiotics
drug combinations
microfluidics
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
20
05
2021
received:
19
12
2020
accepted:
27
05
2021
pubmed:
3
7
2021
medline:
18
11
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
Antibiotic resistance is a worldwide and growing clinical problem. With limited drug development in the antibacterial space, combination therapy has emerged as a promising strategy to combat multidrug-resistant bacteria. Antibacterial combinations can improve antibiotic efficacy and suppress antibacterial resistance through independent, synergistic, or even antagonistic activities. Combination therapies are famously used to treat viral and mycobacterial infections and cancer. However, antibacterial combinations are only now emerging as a common treatment strategy for other bacterial infections owing to challenges in their discovery, development, regulatory approval, and commercial/clinical deployment. Here, we focus on discovery-where the sheer scale of combinatorial chemical spaces represents a significant challenge-and discuss how combination therapy can impact the treatment of bacterial infections. Despite these challenges, recent advancements, including new in silico methods, theoretical frameworks, and microfluidic platforms, are poised to identify the new and efficacious antibacterial combinations needed to revitalize the antibacterial drug pipeline.
Identifiants
pubmed: 34212403
doi: 10.1111/nyas.14649
pmc: PMC8290516
mid: NIHMS1709889
doi:
Substances chimiques
Anti-Bacterial Agents
0
Drug Combinations
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-96Subventions
Organisme : NIAID NIH HHS
ID : U19 AI142780
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : 5U19AI42780
Informations de copyright
© 2021 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences.
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