Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study.
EPIC
Excess iron
Iron overload
Iron status
Serum ferritin
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
21
12
2020
accepted:
24
06
2021
pubmed:
3
7
2021
medline:
27
1
2022
entrez:
2
7
2021
Statut:
ppublish
Résumé
Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 µg/L and 35.2% in males, respectively, and 77 µg/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (~ 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
Identifiants
pubmed: 34213605
doi: 10.1007/s00394-021-02625-w
pii: 10.1007/s00394-021-02625-w
doi:
Substances chimiques
Hemochromatosis Protein
0
Histocompatibility Antigens Class I
0
Ferritins
9007-73-2
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-114Subventions
Organisme : Cancer Research UK
ID : 25004
Pays : United Kingdom
Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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