Lack of support for surface diffusion of postsynaptic AMPARs in tuning synaptic transmission.
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
17 08 2021
17 08 2021
Historique:
received:
14
12
2020
revised:
19
03
2021
accepted:
17
06
2021
pubmed:
3
7
2021
medline:
11
9
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
Repetitive stimulation of excitatory synapses triggers molecular events required for signal transfer across neuronal synapses. It has been hypothesized that one of these molecular events, the diffusion of extrasynaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPARs) (i.e., the diffusion hypothesis), is necessary to help synapses recover from paired-pulse depression. To examine this presumed role of AMPAR diffusion during repetitive presynaptic stimulation, a biophysical model based on published physiological results was developed to track the localization and gating of each AMPAR. The model demonstrates that AMPAR gating in short intervals of fewer than 100 ms is controlled by their position in relation to the glutamate release site and by their recovery from desensitization, but it is negligibly influenced by their diffusion. Therefore, these simulations failed to demonstrate a role for AMPAR diffusion in helping synapses recover from paired-pulse depression.
Identifiants
pubmed: 34214532
pii: S0006-3495(21)00513-0
doi: 10.1016/j.bpj.2021.06.026
pmc: PMC8391035
pii:
doi:
Substances chimiques
Receptors, AMPA
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3409-3417Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103712
Pays : United States
Informations de copyright
Copyright © 2021 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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