Leg movement activity during sleep in multiple sclerosis with and without restless legs syndrome.
multiple sclerosis
periodic limb movements
polysomnography
restless legs syndrome
Journal
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
pubmed:
4
7
2021
medline:
19
2
2022
entrez:
3
7
2021
Statut:
ppublish
Résumé
To carry out an analysis of leg movement activity during sleep in a polysomnography dataset of patients with multiple sclerosis (MS) in comparison to idiopathic restless legs syndrome (iRLS) and healthy controls. In this cross-sectional, observational, instrumental study, 57 patients (males/females: 11/46; mean age 46.2 ± 10.2 years) with a diagnosis of MS underwent a telephone interview assessing the 5 standard diagnostic criteria for RLS and polysomnography. Sleep architecture and leg movement activity during sleep were subsequently compared: 1) 40 patients with MS without RLS (MS-RLS) vs 28 healthy controls; 2) 17 patients with MS with RLS (MS+RLS) vs 35 patients with iRLS; 3) MS+RLS vs MS-RLS. MS-RLS and MS+RLS presented increased sleep latency, percentage of sleep stage N1, and reduced total sleep time compared to healthy controls and iRLS, respectively. The periodic limb movements during sleep (PLMS) index was higher in MS-RLS than in healthy controls ( MS is a risk factor for RLS, PLMS, and for a lower sleep quality in comparison to healthy patients. PLMS in MS+RLS are fewer and shorter if compared to iRLS. Our results suggest a dissociation between motor (PLMS) and sensory symptoms (RLS sensory component) in RLS secondary to MS, with possible treatment implications. Ferri R, Sparasci D, Castelnovo A, et al. Leg movement activity during sleep in multiple sclerosis with and without restless legs syndrome.
Identifiants
pubmed: 34216201
pii: jcsm.9466
doi: 10.5664/jcsm.9466
pmc: PMC8807912
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-20Informations de copyright
© 2022 American Academy of Sleep Medicine.
Références
Neurol Res. 2018 Jul;40(7):586-592
pubmed: 29577828
Nat Rev Neurosci. 2009 Mar;10(3):199-210
pubmed: 19209176
Sleep Med Rev. 2012 Aug;16(4):283-95
pubmed: 21795081
Dev Neuropsychol. 2009;34(5):523-38
pubmed: 20183716
J Clin Endocrinol Metab. 2004 May;89(5):2119-26
pubmed: 15126529
Sleep Med. 2016 Oct;26:86-95
pubmed: 27890390
Eur J Neurol. 2006 Dec;13(12):1333-9
pubmed: 17116216
CNS Neurol Disord Drug Targets. 2012 Dec;11(8):1061-9
pubmed: 23244433
Sleep. 2007 Dec;30(12):1779-85
pubmed: 18246987
J Clin Neurophysiol. 2014 Aug;31(4):375-81
pubmed: 25083851
Lancet Neurol. 2012 Feb;11(2):157-69
pubmed: 22265211
J Neurol Sci. 2012 May 15;316(1-2):158-63
pubmed: 22251932
Brain Behav Immun. 2002 Oct;16(5):503-12
pubmed: 12401464
Sleep Med. 2003 Mar;4(2):101-19
pubmed: 14592341
Sleep. 2020 Mar 12;43(3):
pubmed: 31637431
BMC Neurol. 2018 Aug 24;18(1):123
pubmed: 30143019
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Sleep Med. 2014 Aug;15(8):860-73
pubmed: 25023924
Ann Neurol. 2011 Feb;69(2):292-302
pubmed: 21387374
Ann Neurol. 2012 Jun;71(6):834-44
pubmed: 22718547
Neurobiol Aging. 2014 Sep;35 Suppl 2:S51-8
pubmed: 24929968
Sleep. 2008 Jul;31(7):944-52
pubmed: 18655317
Sleep. 2014 Mar 01;37(3):497-504
pubmed: 24587572
Mult Scler. 2008 Jan;14(1):86-93
pubmed: 17942519
Sleep. 2021 Sep 13;44(9):
pubmed: 33720378
Neurol Sci. 2016 Jan;37(1):57-65
pubmed: 26255301
Sleep Med. 2019 Feb;54:94-100
pubmed: 30529783
N Engl J Med. 2000 Sep 28;343(13):938-52
pubmed: 11006371
Sleep. 2006 Dec;29(12):1587-94
pubmed: 17252889
Mult Scler. 2012 Aug;18(8):1159-69
pubmed: 22183937
CNS Drugs. 2019 Jul;33(7):659-676
pubmed: 31290079
Sleep Med. 2012 Apr;13(4):433-41
pubmed: 22325713
Mult Scler Int. 2012;2012:673936
pubmed: 23316361
Neurologia (Engl Ed). 2019 Apr 5;:
pubmed: 30962014