Scan-rescan repeatability of axonal imaging metrics using high-gradient diffusion MRI and statistical implications for study design.
Axon diameter
Brain
Diffusion MRI
High b-value
Human Connectome Project (HCP)
Human connectom scanner
Reproducibility
Scan-Rescan
Spherical Mean Technique (SMT)
Tissue microstructure
White matter
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
07
01
2021
revised:
12
05
2021
accepted:
26
06
2021
pubmed:
4
7
2021
medline:
21
10
2021
entrez:
3
7
2021
Statut:
ppublish
Résumé
Axon diameter mapping using diffusion MRI in the living human brain has attracted growing interests with the increasing availability of high gradient strength MRI systems. A systematic assessment of the consistency of axon diameter estimates within and between individuals is needed to gain a comprehensive understanding of how such methods extend to quantifying differences in axon diameter index between groups and facilitate the design of neurobiological studies using such measures. We examined the scan-rescan repeatability of axon diameter index estimation based on the spherical mean technique (SMT) approach using diffusion MRI data acquired with gradient strengths up to 300 mT/m on a 3T Connectom system in 7 healthy volunteers. We performed statistical power analyses using data acquired with the same protocol in a larger cohort consisting of 15 healthy adults to investigate the implications for study design. Results revealed a high degree of repeatability in voxel-wise restricted volume fraction estimates and tract-wise estimates of axon diameter index derived from high-gradient diffusion MRI data. On the region of interest (ROI) level, across white matter tracts in the whole brain, the Pearson's correlation coefficient of the axon diameter index estimated between scan and rescan experiments was r = 0.72 with an absolute deviation of 0.18 μm. For an anticipated 10% effect size in studies of axon diameter index, most white matter regions required a sample size of less than 15 people to observe a measurable difference between groups using an ROI-based approach. To facilitate the use of high-gradient strength diffusion MRI data for neuroscientific studies of axonal microstructure, the comprehensive multi-gradient strength, multi-diffusion time data used in this work will be made publicly available, in support of open science and increasing the accessibility of such data to the greater scientific community.
Identifiants
pubmed: 34216774
pii: S1053-8119(21)00599-1
doi: 10.1016/j.neuroimage.2021.118323
pmc: PMC8646020
mid: NIHMS1741051
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
118323Subventions
Organisme : NIMH NIH HHS
ID : U01 MH093765
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS078044
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB030006
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023043
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS096056
Pays : United States
Organisme : NIBIB NIH HHS
ID : R00 EB015445
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS118187
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR019307
Pays : United States
Organisme : NIBIB NIH HHS
ID : U01 EB026996
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB006847
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015896
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023401
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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