Plasma Cell Vulvitis: A Systematic Review.
Journal
Journal of lower genital tract disease
ISSN: 1526-0976
Titre abrégé: J Low Genit Tract Dis
Pays: United States
ID NLM: 9704963
Informations de publication
Date de publication:
01 Oct 2021
01 Oct 2021
Historique:
pubmed:
6
7
2021
medline:
15
12
2021
entrez:
5
7
2021
Statut:
ppublish
Résumé
This systematic review aimed to present the available literature on plasma cell vulvitis (PCV), a relatively uncommon form of inflammatory vulvovaginal dermatitis. A literature search was performed in PubMed, Science Direct, and Google Scholar using the following key words: "plasma cell vulvitis," "Zoon vulvitis," and "vulvitis circumscripta plasmacellularis." Specific variables were assessed in each article, including patient age, menopausal status, comorbidities, presenting symptoms, symptom duration, histological description, treatment, and treatment response. Thirty-nine articles met inclusion criteria, including 38 case reports and 1 observational study, with a total of 96 cases of PCV reported. The mean age of diagnosis was 52.9 years, with an age range of 8-76 years. Most common presenting symptoms included pruritis and vaginal discomfort, with average duration of symptoms 28.2 months (range = 2 months to 10 years). All reports demonstrated subepithelial plasma cell infiltrate on histology. Five percent of PCV cases reported concomitant autoimmune conditions and 6% sexually transmitted infections. Most common treatment modalities included topical corticosteroids (n = 41), tacrolimus (n = 6), and imiquimod (n = 6). In 53 reported outcomes, 88.7% of patients had resolution of symptoms with treatment. Clinical research is needed to better determine the diagnostic criteria and to assess the efficacy of treatment options for PCV.
Identifiants
pubmed: 34224535
doi: 10.1097/LGT.0000000000000617
pii: 00128360-202110000-00011
doi:
Substances chimiques
Imiquimod
P1QW714R7M
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
312-317Informations de copyright
Copyright © 2021, ASCCP.
Déclaration de conflit d'intérêts
A.T.G. reports grants from Elen, Cellular Medicine Association, and Gynecologic Cancers Research Foundation, during the conduct of the study, personal fees from Amag, grants and personal fees from Ipsen, grants from Endoceutics, and grants and personal fees from SST, outside the submitted work, and is the founder and president of the Gynecologic Cancers Research Foundation, a 501c3. The other authors have declared they have no conflicts of interest.
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