Cardiac involvement in consecutive unselected hospitalized COVID-19 population: In-hospital evaluation and one-year follow-up.
COVID-19
Cardiovascular disease
Cardiovascular magnetic resonance
Echocardiography
Follow-up
Myocarditis
Journal
International journal of cardiology
ISSN: 1874-1754
Titre abrégé: Int J Cardiol
Pays: Netherlands
ID NLM: 8200291
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
received:
12
05
2021
revised:
26
06
2021
accepted:
30
06
2021
pubmed:
6
7
2021
medline:
9
9
2021
entrez:
5
7
2021
Statut:
ppublish
Résumé
Cardiovascular disease (CVD) can occur in COVID-19 and has impact on clinical course. Data on CVD prevalence in hospitalized COVID-19 patients and sequelae in survivors is limited. Aim of this prospective study carried out on consecutive unselected COVID-19 population, was to assess: 1) CVD occurrence among hospitalized COVID-19 patients, 2) persistence or new onset of CVD at one-month and one-year follow-up. Over 30 days n = 152 COVID-19 patients underwent cardiovascular evaluation. Standard electrocardiogram (ECG), Troponin and echocardiography were integrated by further tests when indicated. Medical history, arterial blood gas, blood tests, chest computed tomography and treatment were recorded. CVD was defined as the occurrence of a new condition during the hospitalization for COVID-19. Survivors attended a one-month follow-up visit and a one-year telephone follow-up. Forty-two patients (28%) experienced a wide spectrum of CVD with acute myocarditis being the most frequent. Death occurred in 32 patients (21%) and more frequently in patients who developed CVD (p = 0.032). After adjustment for confounders, CVD was independently associated with death occurrence. At one-month follow-up visit, 7 patients (9%) presented persistent or delayed CVD. At one-year telephone follow-up, 57 patients (48%) reported persistent symptoms. Cardiovascular evaluation in COVID-19 patients is crucial since the occurrence of CVD in hospitalized COVID-19 patients is common (28%), requires specific treatment and increases the risk of in-hospital mortality. Persistence or delayed presentation of CVD at 1-month (9%) and persistent symptoms at 1-year follow-up (48%) suggest the need for monitoring COVID-19 survivors.
Sections du résumé
BACKGROUND
Cardiovascular disease (CVD) can occur in COVID-19 and has impact on clinical course. Data on CVD prevalence in hospitalized COVID-19 patients and sequelae in survivors is limited. Aim of this prospective study carried out on consecutive unselected COVID-19 population, was to assess: 1) CVD occurrence among hospitalized COVID-19 patients, 2) persistence or new onset of CVD at one-month and one-year follow-up.
METHODS
Over 30 days n = 152 COVID-19 patients underwent cardiovascular evaluation. Standard electrocardiogram (ECG), Troponin and echocardiography were integrated by further tests when indicated. Medical history, arterial blood gas, blood tests, chest computed tomography and treatment were recorded. CVD was defined as the occurrence of a new condition during the hospitalization for COVID-19. Survivors attended a one-month follow-up visit and a one-year telephone follow-up.
RESULTS
Forty-two patients (28%) experienced a wide spectrum of CVD with acute myocarditis being the most frequent. Death occurred in 32 patients (21%) and more frequently in patients who developed CVD (p = 0.032). After adjustment for confounders, CVD was independently associated with death occurrence. At one-month follow-up visit, 7 patients (9%) presented persistent or delayed CVD. At one-year telephone follow-up, 57 patients (48%) reported persistent symptoms.
CONCLUSION
Cardiovascular evaluation in COVID-19 patients is crucial since the occurrence of CVD in hospitalized COVID-19 patients is common (28%), requires specific treatment and increases the risk of in-hospital mortality. Persistence or delayed presentation of CVD at 1-month (9%) and persistent symptoms at 1-year follow-up (48%) suggest the need for monitoring COVID-19 survivors.
Identifiants
pubmed: 34224766
pii: S0167-5273(21)01094-9
doi: 10.1016/j.ijcard.2021.06.056
pmc: PMC8253670
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
235-242Investigateurs
Albante Alida
(A)
Araimo Morselli Fabio
(AM)
Auricchio Daniela
(A)
Letizia D'Antoni
(L)
Barletta Giovanna
(B)
Bilotta Federico
(B)
Brisciani Matteo
(B)
Bruno Katia
(B)
Bucarelli Maria Clelia
(BM)
Cappannoli Alessandro
(C)
Ceccarelli Giancarlo
(C)
Celli Paola
(C)
Consolo Stella
(C)
Consoli Giulia
(C)
Croce Claudia
(C)
Crocitti Beatrice
(C)
D'Antoni Letizia
(D)
De Lazzaro Francesco
(L)
De Lauri Daniela
(L)
De Rose Maria
(R)
Del Bianco Andrea
(DB)
Di Bella Valerio
(DB)
Di Sano Laura
(DS)
Di Santo Carmela
(DS)
Francavilla Santi
(F)
Giannetti Lorena
(G)
Giordano Giovanni
(G)
Ianni Stefano
(I)
Imperiale Carmela
(I)
Maestrini Ilaria
(M)
Magnanimi Eugenia
(M)
Manganelli Chiara
(M)
Maldarelli Federica
(M)
Martelli Sabina
(M)
Messina Teresa
(M)
Novelli Martina
(N)
Pasculli Patrizia
(P)
Pasqualitto Fabiola
(P)
Pattelli Elisa
(P)
Pecorari Filippo
(P)
Perrella Serena
(P)
Petroianni Angelo
(P)
Piazzolla Mario
(P)
Portieri Monica
(P)
Prosperi Silvia
(P)
Rachele Edoardo Sebastian
(RE)
Ratini Fabiola
(R)
Ricci Claudia
(R)
Romano Hilde
(R)
Sabani Anna
(S)
Santopietro Pietro
(S)
Tellan Guglielmo
(T)
Titi Luca
(T)
Tordiglione Paolo
(T)
Tosi Antonella
(T)
Trigilia Fausto
(T)
Verduci Noemi
(V)
Vaccaro Paola
(V)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
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