Homeostatic Function and Inflammatory Activation of Ileal CD8
Anti-T Cell Trafficking Agents
CD8(+) Tissue-Resident T Cell
Gut Compartmentalization
Transcriptome
Journal
Cellular and molecular gastroenterology and hepatology
ISSN: 2352-345X
Titre abrégé: Cell Mol Gastroenterol Hepatol
Pays: United States
ID NLM: 101648302
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
11
2020
revised:
26
06
2021
accepted:
28
06
2021
pubmed:
6
7
2021
medline:
29
3
2022
entrez:
5
7
2021
Statut:
ppublish
Résumé
Tissue-resident memory T (Trm) cells, both of the CD4 and CD8 lineage, have been implicated in disease flares in inflammatory bowel disease. However, data are conflicting regarding the profile of human CD8 Here, we performed imaging mass cytometry, flow cytometry, and RNA-sequencing to compare lamina propria and intraepithelial CD103 Our data revealed that lamina propria CD103 Altogether, these compartmental and inflammation-induced differences indicate that therapeutic strategies could have a different impact on the same immune cells depending on the local compartment and presence of an inflammatory milieu, and should be taken into account when investigating short- and long-term effects of new gut T cell-targeting drugs.
Sections du résumé
BACKGROUND & AIMS
Tissue-resident memory T (Trm) cells, both of the CD4 and CD8 lineage, have been implicated in disease flares in inflammatory bowel disease. However, data are conflicting regarding the profile of human CD8
METHODS
Here, we performed imaging mass cytometry, flow cytometry, and RNA-sequencing to compare lamina propria and intraepithelial CD103
RESULTS
Our data revealed that lamina propria CD103
CONCLUSIONS
Altogether, these compartmental and inflammation-induced differences indicate that therapeutic strategies could have a different impact on the same immune cells depending on the local compartment and presence of an inflammatory milieu, and should be taken into account when investigating short- and long-term effects of new gut T cell-targeting drugs.
Identifiants
pubmed: 34224909
pii: S2352-345X(21)00137-5
doi: 10.1016/j.jcmgh.2021.06.022
pmc: PMC8551698
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1567-1581Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.